Abstract
The present research evaluated differential effects of sodium selenite and nano-Se on growth performance, tissue Se distribution, and glutathione peroxidase (GSH-Px) activity of avian broiler. Broilers were randomly segregated into 12 groups so that three replicates were available for each of the three treatments (T-1, T-2, and T-3) and control groups. The control groups were fed basal diets without Se addition. T-1, T-2, and T-3 were fed with diets containing 0.2 mg kg−1 sodium selenite, 0.2 mg kg−1 nano-Se, and 0.5 mg kg−1 nano-Se, respectively. Compared with the control, Se supplementation remarkably improved daily weight gain and survival rate and decreased feed conversion ratio (P < 0.05). However, no significant difference was observed between T-1, T-2, and T-3. The tissue Se content was significantly higher (P < 0.05) in Se-supplemented groups than the control, and T-3 showed the highest. Furthermore, higher Se content was observed in liver, and there was a significant difference (P < 0.05) compared with that in muscle. As for serum and hepatic GSH-Px activities, Se supplementation remarkably improved GSH-Px activity (P < 0.05), and there was no significant difference (P > 0.05) between treatments (T-1, T-2, and T-3).
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References
Combs GF, Combs SB (1986) The role of selenium in nutrition. Academic, Toronto
Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:585–590
Rayman MP (2000) The importance of selenium to human health. Lancet 356:233–241
Dhur A, Galan P, Hercberg S (1990) Relationship between selenium, immunity and resistance against infection. Comp Biochem Physiol C 96:271–280
Avanzo JL, Junior XM, Cesar CM (2002) Role of antioxidant systems in induced nutritional pancreatic atrophy in chicken. Comp Biochem Physiol B 131:815–823
Pappas AC, Karadas F, Surai PF, Speake BK (2005) The selenium intake of the female chicken influences the selenium status of her progeny. Comp Biochem Physiol B 142:465–474
Golubkina NA, Papazyan TT (2006) Selenium distribution in eggs of avian species. Comp Biochem Phys B 145:384–388
Zhang JS, Gao XY, Zhang LD, Bao YP (2001) Biological effects of a nano red elemental selenium. Biofactors 15:27–38
Zhang JS, Wang H, Yan X, Zhang LD (2004) Comparison of short-term toxicity between nano-Se and selenite in mice. Life Sci 75:447–459
Jia X, Li N, Chen J (2005) A subchronic toxicity study of elemental nano-Se in Sprague Dawley rats. Life Sci 76:1989–2003
Huang B, Zhang J, Hou J, Chen C (2003) Free radical scavenging efficiency of nano-Se in vitro. Free Radic Biol Med 35:805–813
Wang HL, Zhang JS, Yu HQ (2007) Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radical Bio Med 42:1524–1533
National Research Council (1994) Nutrient requirements of poultry, 9th revised edition. National Academy Press, Washington, DC
Tinggi U (1999) Determination of selenium in meat products by hydride generation atomic absorption spectrophotometry. J AOAC Int 82:364–367
Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158–169
Lawrence RA, Burke RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71:952–958
Utterback PL, Parsons CM, Yoon I, Butler J (2005) Effect of supplementing selenium yeast in diets of laying hens on egg selenium content. Poult Sci 84:1900–1901
Zuberbuehler CA, Messikommer RE, Arnold MM, Forrer RS, Wenk C (2006) Effects of selenium depletion and selenium repletion by choice feeding on selenium status of young and old laying hens. Physiol Behav 87:430–440
Singh H, Sodhi S, Kaur R (2006) Effects of dietary supplements of selenium, vitamin E or combinations of the two on antibody responses of broilers. Br Poult Sci 47:714–719
Mahmoud KZ, Edens FW (2005) Influence of organic selenium on hsp70 response of heat-stressed and enteropathogenic Escherichia coli-challenged broiler chickens (Gallus gallus). Comp Biochem Phys C 141:69–75
Choct M, Naylor AJ, Reinke N (2004) Selenium supplementation affects broiler growth performance, meat yield and feather coverage. Br Poult Sci 45:677–683
Gries CL, Scott ML (1972) Pathology of selenium deficiency in the chick. J Nutr 102:1287–1296
Chang WP, Hom JSH, Dietert RR, Combs GF, Marsh JA (1994) Effect of dietary vitamin E and selenium deficiency on chicken splenocyte proliferan and cell surface marker expression. Immunopharm Immunot 16:203–223
Chang WP, Combs GF, Scanes CG, Marsh JA (2005) The effects of dietary vitamin E and selenium deficiencies on plasma thyroid and thymic hormone concentrations in the chicken. Dev Comp Immunol 29:265–273
Pan C, Huang K, Zhao Y, Qin S, Chen F, Hu Q (2007) Effect of selenium source and level in hen’s diet on tissue selenium deposition and egg selenium concentrations. J Agric Food Chem 55:1027–1032
Diskin CJ, Tomasso CL, Alper JC, Glaser ML, Fliegel SE (1979) Long-term selenium exposure. Arch Intern Med 139:824–826
Segalés J, Allan GM, Domingo M (2005) Porcine circovirus diseases. Anim Health Res Rev 6:119–142
Yu HJ, Liu JQ, Böck A, Li J, Luo GM, Shen JC (2005) Engineering glutathione transferase to a novel glutathione peroxidase mimic with high catalytic efficiency. J Biol Chem 280:11930–11935
Omaye ST, Tappel AL (1974) Effect of dietary selenium on glutathione peroxidase in the chick. J Nutr 104:747–753
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This study was supported by the Doctoral Natural Science Foundation of University (No. 1110XJ-030628). We also acknowledge valuable help provided by all involved workers.
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Wang, Y. Differential Effects of Sodium Selenite and Nano-Se on Growth Performance, Tissue Se Distribution, and Glutathione Peroxidase Activity of Avian Broiler. Biol Trace Elem Res 128, 184–190 (2009). https://doi.org/10.1007/s12011-008-8264-y
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DOI: https://doi.org/10.1007/s12011-008-8264-y