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Effect of tannery effluent on oxidative status of brain structures and liver of rodents

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Abstract

Oxidative stress has been considered as a central mechanism of toxicity induced by xenobiotics. Previously, it was demonstrated that mice exposed to tannery effluent showed an anxiety-like behavior, without any comparable behavioral effects in rats. The aim of the present study was to investigate the impact of tannery wastewater on oxidative status in in vitro and in vivo assays with two mammal species, mice and rats. Specifically, homogenates of two brain areas and the liver were incubated with tannery wastewater; reactive species and lipid peroxidation levels and antioxidant enzyme activities were detected. In addition, the effects of in vivo exposure of mice to tannery effluents on and lipid peroxidation levels and the total reactive antioxidant capacity in brain areas and liver. Brain areas, the hippocampus and frontal cortex, and the liver of mice exposed to tannery wastewater showed oxidative stress. Our data suggest that divergent species-dependent hepatic enzymes adaptations, such as glutathione peroxidase and glutathione S-transferase activities, induced by tannery effluent could explain previous behavioral findings.

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Acknowledgments

This work was supported by the Brazilian funding agencies: Fundação de Amparo à Pesquisa do Rio Grande do Sul—PROCOREDES III; FAPERGS/1981-2551/13-4; FUNADESP/UNIVATES; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—CAPES (Dr. F. S. Moysés); Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq (Dr. I.R. Siqueira; Dr. M.A.S. Rodrigues; Dr. S. Stülp; Dr. F. S. Moysés; Dr. V.R. Elsner; Dr. K. Bertoldi).

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Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências Biológicas – Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

    Felipe dos Santos Moysés, Karine Bertoldi, Viviane Rostirola Elsner, Laura Reck Cechinel, Carla Basso & Ionara Rodrigues Siqueira

  2. Departamento de Ciências Biológicas, Universidade Regional Integrada do Alto Uruguai e das Missões, Erechim, RS, Brazil

    Felipe dos Santos Moysés

  3. Programa de Pós-Graduação em Ambiente e Desenvolvimento, Univates, Lajeado, RS, Brazil

    Simone Stülp

  4. Programa de Pós-Graduação em Qualidade Ambiental, Universidade Feevale – FEEVALE, Novo Hamburgo, RS, Brazil

    Marco Antônio Siqueira Rodrigues

  5. Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500 sala 202, Porto Alegre, RS, 90050-170, Brazil

    Ionara Rodrigues Siqueira

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  1. Felipe dos Santos Moysés
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  2. Karine Bertoldi
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  3. Viviane Rostirola Elsner
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  4. Laura Reck Cechinel
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  5. Carla Basso
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  6. Simone Stülp
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  7. Marco Antônio Siqueira Rodrigues
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  8. Ionara Rodrigues Siqueira
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Correspondence to Ionara Rodrigues Siqueira.

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The NIH “Guide for the Care and Use of Laboratory Animals” (NIH publication No. 80-23, revised 1996) was followed in all experiments that were conducted at room temperature (22 ± 1 °C). All experiments were approved by the Local Institutional Research Committee).

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The authors declare that they have no conflicts of interest.

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dos Santos Moysés, F., Bertoldi, K., Elsner, V.R. et al. Effect of tannery effluent on oxidative status of brain structures and liver of rodents. Environ Sci Pollut Res 24, 15689–15699 (2017). https://doi.org/10.1007/s11356-017-9149-4

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