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Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review

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Abstract

Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved to human populations. The purpose of this article is to provide a comprehensive review on genotoxicity induced by fluoride on the basis of its mechanisms of action. In the last 10 years, all published data showed some evidence related to genotoxicity, which is due to mitochondrial disruption, oxidative stress, and cell cycle disturbances. However, this is an area that still requires a lot of investigation since the published data are not sufficient for clarifying the genotoxicity induced by fluoride. Certainly, the new information will be added to those already established for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.

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Acknowledgments

DAR and MBV are fellowships from CNPq (Conselho Nacional de Desenvolvimento Cientifico and Tecnologico, Brazil).

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Authors and Affiliations

  1. Department of Pathology, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil

    Daniel Araki Ribeiro, Veronica Quispe Yujra & Celina Tizuko Fujiyama Oshima

  2. Department of Biosciences, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil

    Daniel Araki Ribeiro, Victor Hugo Pereira da Silva, Samuel Rangel Claudio, Debora Estadella & Milena de Barros Viana

  3. Departamento de Biociências, Universidade Federal de São Paulo, UNIFESP, Av. Ana Costa, 95, Vila Mathias, Santos, SP, 11060-001, Brazil

    Daniel Araki Ribeiro

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  1. Daniel Araki Ribeiro
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  2. Veronica Quispe Yujra
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Correspondence to Daniel Araki Ribeiro.

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Responsible editor: Philippe Garrigues

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Ribeiro, D.A., Yujra, V.Q., da Silva, V.H.P. et al. Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review. Environ Sci Pollut Res 24, 15254–15259 (2017). https://doi.org/10.1007/s11356-017-9105-3

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  • DOI: https://doi.org/10.1007/s11356-017-9105-3

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