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The structural and functional effects of fine particulate matter from cooking oil fumes on rat umbilical cord blood vessels

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Abstract

A growing body of epidemiological evidence has supported the association between maternal exposure to airborne fine particulate matter (PM2.5) during pregnancy and adverse pregnancy outcomes. However, the specific biological mechanisms implicated in the causes of adverse pregnancy outcomes are not well defined. In this study, a pregnant rat model of exposure to different doses of cooking oil fumes (COFs)-derived PM2.5 by tail intravenous injection in different pregnant stages was established. The results indicated that exposure to COFs-derived PM2.5 was associated with adverse pregnancy outcomes, changed the structure of umbilical cord blood vessels, decreased the diameter and lumen area, and increased wall thickness. What’s more, a significant increase of maximum contraction tension was observed in the early pregnancy high-dose exposure group and pregnant low-dose exposure group compared to the control group. Based on the maximum contraction tension, acetylcholine (ACh) did not induce vasodilation but caused a dose-dependent constriction, and there were significant differences in the two groups compared to the control group. Exposure to COFs-derived PM2.5 impaired the vasomotor function of umbilical veins by affecting the expression of NO and ET-1. This is the first study that evaluated the association of risk of adverse pregnancy outcomes and pregnant rats exposed to COFs-derived PM2.5 and primarily explored the potential mechanisms of umbilical cord blood vessels injury on a rat model. More detailed vitro and vivo studies are needed to further explore the mechanism in the future.

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Acknowledgments

This work was supported by the Science Research Fund of Anhui Province (090413265X). We are grateful to thank all of the participants in this study and the reviewers and editors for their work.

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Authors and Affiliations

  1. Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China

    Xiaoxia Zhu, Lijuan Hou, Jian Zhang, Cijiang Yao, Ying Liu, Chao Zhang & Yachun Xu

  2. The Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China

    Jiyu Cao

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  1. Xiaoxia Zhu
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  2. Lijuan Hou
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  3. Jian Zhang
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  4. Cijiang Yao
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  5. Ying Liu
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  6. Chao Zhang
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  7. Yachun Xu
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  8. Jiyu Cao
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Correspondence to Jiyu Cao.

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Responsible editor: Philippe Garrigues

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Zhu, X., Hou, L., Zhang, J. et al. The structural and functional effects of fine particulate matter from cooking oil fumes on rat umbilical cord blood vessels. Environ Sci Pollut Res 23, 16567–16578 (2016). https://doi.org/10.1007/s11356-016-6821-z

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  • DOI: https://doi.org/10.1007/s11356-016-6821-z

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