Abstract
The aim of this study is to evaluate the presence of perfluoroalkyl substances (PFASs) in the blood of 46 residents from Barcelona and to study the factors that affect exposure. Compounds analysed included perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), perfluorobutane sulfonate (PFBS), perfluorooctanoate acid (PFOA) and perfluorononanoate acid (PFNA). Blood was liquid–liquid extracted and PFASs were determined by liquid chromatography coupled to tandem mass spectrometry. Good recoveries (between 97 ± 14 and 105 ± 13 %) were obtained and method detection limits were from 0.03 to 0.07 ng mL−1. ΣPFASs ranged from 0.11 to 4.37 ng mL−1. PFOS was the main compound detected at 0.09–3.35 ng mL−1, followed by PFOA and PFHxS. PFBS and PFNA were seldom detected. Working conditions, smoking and gender did not cause any significant differences among ΣPFASs levels in the blood while age and parity produced decreased concentrations. On the other hand, laboratory working conditions produced significant higher PFOA levels compared to the general population. Compared to other studies, the PFASs levels in blood from Barcelona residents is low (mean ΣPFASs of 1.67 ± 0.88 ng mL−1) and with little variation among the studied population.
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References
Bao J, Liu W, Liu L, Jin Y, Dai J, Ran X, Zhang Z, Tsuda S (2011) Perfluorinated compounds in the environment and the blood of residents living near fluorochemical plants in Fuxin. China Environ Sci Technol 45:8075–8080
Bonefeld-Jorgensen EC, Long M, Bossi R, Ayotte P, Asmund G, Krüger T, Ghisari M, Mulvad G, Kern P, Nzulumiki P, Dewailly E (2011) Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study. Environ Health: Glob Access Sci Source 10:88–104
Brantsæter AL, Whitworth KW, Ydersbond TA, Haug LS, Haugen M, Knutsen HK, Thomsen C, Meltzer HM, Becher G, Sabaredzovic A, Hoppin JA, Eggesbø M, Longnecker MP (2013) Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women. Environ Int 54:74–84
Cherrie JW, Semple S, Christopher Y, Saleem A, Hughson GW, Philips A (2006) How important is inadvertent ingestion of hazardous substances at work? Ann Occup Hyg 50:693–704
Cui L, Liao CY, Zhou QF, Xia TM, Yun ZJ, Jiang GB (2010) Excretion of PFOA and PFOS in male rats during a subchronic exposure. Arch Environ Contam Toxicol 58:205–213
Ericson I, Gomez M, Nadal M, van Bavel B, Lindstrom G, Domingo JL (2007) Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: a pilot study. Environ Int 33:616–623
Fernandez-Sanjuan M, Meyer J, Damasio J, Faria M, Barata C, Lacorte S (2010) Screening of perfluorinated chemicals (PFCs) in various aquatic organisms. Anal Bioanal Chem 398:1447–1456
Fromme H, Midasch O, Twardella D, Angerer J, Boehmer S, Liebl B (2007) Occurrence of perfluorinated substances in an adult German population in southern Bavaria. Int Arch Occup Environ Health 80:313–319
Fromme H, Tittlemier SA, Völkel W, Wilhelm M, Twardella D (2009) Perfluorinated compounds—exposure assessment for the general population in western countries. Int J Hyg Environ Health 212:239–270
Gómez C, Vicente J, Echavarri-Erasun B, Porte C, Lacorte S (2011) Occurrence of perfluorinated compounds in water, sediment and mussels from the Cantabrian Sea (North Spain). Mar Pollut Bull 62:948–955
Gómez-Canela C, Barth JAC, Lacorte S (2012) Occurrence and fate of perfluorinated compounds in sewage sludge from Spain and Germany. Environ Sci Pollut Res 19:4109–4119
Guo F, Zhong Y, Wang Y, Li J, Zhang J, Liu J, Zhao Y, Wu Y (2011) Perfluorinated compounds in human blood around Bohai Sea, China. Chemosphere 85:156–162
Herzke D, Huber S, Bervoets L, D’Hollander W, Hajslova J, Pulkrabova J, Brambilla G, De Filippis SP, Klenow S, Heinemeyer G, de Voogt P (2013) Perfluorinated alkylated substances in vegetables collected in four European countries; occurrence and human exposure estimations. Environ Sci Pollut Res 20:7930–7939
Ji K, Kim S, Kho Y, Paek D, Sakong J, Ha J, Choi K (2012) Serum concentrations of major perfluorinated compounds among the general population in Korea: dietary sources and potential impact on thyroid hormones. Environ Int 45:78–85
Kärrman A, van Bavel B, Järnberg U, Hardell L, Lindström G (2006) Perfluorinated chemicals in relation to other persistent organic pollutants in human blood. Chemosphere 64:1582–1591
Kärrman A, Langlois I, Bv B, Lindström G, Oehme M (2007) Identification and pattern of perfluorooctane sulfonate (PFOS) isomers in human serum and plasma. Environ Int 33:782–788
Lien GW, Wen TW, Hsieh WS, Wu KY, Chen CY, Chen PC (2011) Analysis of perfluorinated chemicals in umbilical cord blood by ultra-high performance liquid chromatography/tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 879:641–646
Lü H, Cai QY, Jones KC, Zeng QY, Katsoyiannis A (2014) Levels of organic pollutants in vegetables and human exposure through diet: a review. Crit Rev Environ Sci Technol 44:1–33
Midasch O, Schettgen T, Angerer J (2006) Pilot study on the perfluorooctanesulfonate and perfluorooctanoate exposure of the German general population. Int J Hyg Environ Health 209:489–496
Pan Y, Shi Y, Wang J, Cai Y, Wu Y (2010) Concentrations of perfluorinated compounds in human blood from twelve cities in China. Environ Toxicol Chem 29:2695–2701
Porpora MG, Lucchini R, Abballe A, Ingelido AM, Valentini S, Fuggetta E, Cardi V, Ticino A, Marra V, Fulgenzi AR, De Felip E (2013) Placental transfer of persistent organic pollutants: a preliminary study on mother-newborn pairs. Int J Environ Res Public Health 10:699–711
Rylander C, Sandanger TM, Frøyland L, Lund E (2010) Dietary patterns and plasma concentrations of perfluorinated compounds in 315 Norwegian women: the NOWAC postgenome study. Environ Sci Technol 44:5225–5232
Vassiliadou I, Costopoulou D, Ferderigou A, Leondiadis L (2010) Levels of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) in blood samples from different groups of adults living in Greece. Chemosphere 80:1199–1206
Wilhelm M, Angerer J, Fromme H, Hölzer J (2009) Contribution to the evaluation of reference values for PFOA and PFOS in plasma of children and adults from Germany. Int J Hyg Environ Health 212:56–60
Zhang T, Sun H, Lin Y, Wang L, Zhang X, Liu Y, Geng X, Zhao L, Li F, Kannan K (2011a) Perfluorinated compounds in human blood, water, edible freshwater fish, and seafood in China: daily intake and regional differences in human exposures. J Agric Food Chem 59:11168–11176
Zhang W, Lin Z, Hu M, Wang X, Lian Q, Lin K, Dong Q, Huang C (2011b) Perfluorinated chemicals in blood of residents in Wenzhou, China. Ecotoxicol Environ Saf 74:1787–1793
Zhang Y, Beesoon S, Zhu L, Martin JW (2013) Isomers of perfluorooctanesulfonate and perfluorooctanoate and total perfluoroalkyl acids in human serum from two cities in North China. Environ Int 53:9–17
Acknowledgements
Montserrat March, the nurse from our institute is acknowledged for organising the extraction of blood from workers from the Department of Environmental Chemistry of IDAEA-CSIC. Our friends, Anna Daví and Patricia López, are acknowledged for the extraction of blood of the “general population”. All donors are deeply thanked for their contribution and interest in the study.
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Gómez-Canela, C., Fernández-Sanjuan, M., Farrés, M. et al. Factors affecting the accumulation of perfluoroalkyl substances in human blood. Environ Sci Pollut Res 22, 1480–1486 (2015). https://doi.org/10.1007/s11356-014-3439-x
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DOI: https://doi.org/10.1007/s11356-014-3439-x