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Biological production of xylitol by using nonconventional microbial strains

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Abstract

Xylitol (C5H12O5), an amorphous sugar alcohol of crystalline texture has received great interest on the global market due to its numerous applications in different industries. In addition to its high anticariogenic and sweetening properties, characteristics such as high solubility, stability and low glycemic index confer xylitol its fame in the food and odontological industries. Moreover, it also serves as a building-block in the production of polymers. As a result of the harmful effects of the chemical production of xylitol, the biotechnological means of producing this polyol have evolved over the decades. In contrast to the high consumption of energy, long periods of purification, specialized equipment and high production cost encountered during its chemical synthesis, the biotechnological production of xylitol offers advantages both to the economy and the environment. Non-Saccharomyces yeast strains, also termed as nonconventional, possess the inherent capacity to utilize d-xylose as a sole carbon source, unlike Saccharomyces species.

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Funding

This work was supported by the National Key R & D Program of China (Grant No. 2018YFA0905500), National Natural Science Foundation of China (Grant Nos. 22178169, 21978130, 22078151, 22008113), Jiangsu Agricultural Science and Technology Independent Innovation Fund Project 164 (Grant No. CX(21)3120), Jiangsu Province Natural Science Foundation for Youths (Grant No. BK20200683), Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture (Grant No. XTD2215) and China Postdoctoral Science Foundation (Grant No. 2020M671465).

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CM: designed and wrote the main manuscript text, YF, JS and RP: prepared the figure and tables, YJ, WJ, WZ, FX and MJ: read and approved the manuscript.

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Correspondence to Fengxue Xin.

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The authors have no competing interests to declare that are relevant to the content of this article.

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Manishimwe, C., Feng, Y., Sun, J. et al. Biological production of xylitol by using nonconventional microbial strains. World J Microbiol Biotechnol 38, 249 (2022). https://doi.org/10.1007/s11274-022-03437-8

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  • DOI: https://doi.org/10.1007/s11274-022-03437-8

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