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Validity of urine neutrophile gelatinase-associated lipocalin in children with primary vesicoureteral reflux

  • Urology - Original Paper
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Abstract

Background

Vesicoureteral reflux (VUR) is the most common congenital urinary tract abnormality in children. The objective of this study was to evaluate the diagnostic value of urine neutrophil gelatinase-associated lipocalin (NGAL) in children with primary vesicoureteral reflux (VUR).

Materials and methods

A total of 69 patients were evaluated in 2 groups with (32) and without (37) VUR. Patients with secondary VUR, infectious or inflammatory disorders, obstructive uropathies, and acute or chronic kidney disease were excluded. Urine NGAL level was measured by ELISA kit.

Results

Mean age of children with VUR was 36.84 ± 28.16, compared to those without VUR 32.32 ± 29.08, with no significant difference (p = 0.51). Mean urine NGAL (p = 0.012) and urine NGAL/Cr (p = 0.003) were higher in patients with VUR. In addition, urine NGAL/Cr increased significantly in patients with decreased parenchymal function, compared to those with normal DMSA scan. Using the cutoff value of 0.888, urine NGAL had 84% sensitivity and 81% specificity for diagnosis of VUR. Based on AUC (0.86), urine NGAL had acceptable diagnostic accuracy in children with VUR.

Conclusion

The results of this study support the evidence that urine NGAL/Cr is a sensitive, specific and accurate biomarker for diagnosis of children with primary VUR.

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Authors and Affiliations

  1. Pediatric Nephrology Department, Iran University Medical Sciences, Tehran, Iran

    Azar Nickavar

  2. Chronic Renal Failure Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Ehsan Valavi

  3. Neonatal and Children’s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran

    Baranak Safaeian

  4. Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mostafa Moosavian

Authors
  1. Azar Nickavar
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  2. Ehsan Valavi
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  3. Baranak Safaeian
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  4. Mostafa Moosavian
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Correspondence to Ehsan Valavi.

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Nickavar, A., Valavi, E., Safaeian, B. et al. Validity of urine neutrophile gelatinase-associated lipocalin in children with primary vesicoureteral reflux. Int Urol Nephrol 52, 599–602 (2020). https://doi.org/10.1007/s11255-019-02355-3

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  • DOI: https://doi.org/10.1007/s11255-019-02355-3

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