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Hemodialysis is associated with higher serum FGF23 level when compared with peritoneal dialysis

  • Nephrology - Original Paper
  • Published:
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Abstract

Background

Considering the growing relevance of fibroblast growth factor-23 (FGF23) and increased cardiovascular mortality in dialysis population, an analysis was performed to assess the influence of dialysis modality (peritoneal dialysis and hemodialysis) on level of FGF23.

Methods

A cross-sectional study was performed in 80 continuous ambulatory peritoneal dialysis (CAPD) and 65 hemodialysis (HD) patients without residual renal function. Levels of calcium, phosphate, parathyroid hormone and FGF23 were measured, and their correlations were analyzed. Data on demographics, dialysis modality and FGF23 level were also analyzed.

Results

A significant correlation was found between FGF23 and serum calcium, serum phosphate and dialysis vintage in dialysis patients. Level of FGF23 was significantly higher in hemodialysis patients than that in peritoneal dialysis population. Multivariable regression revealed that, compared to CAPD, hemodialysis was found to be a predictor for higher FGF23 level, which was independent of serum calcium and phosphate level (P < 0.05).

Conclusions

These findings demonstrate that FGF23 levels are significantly higher in hemodialysis patients than that in peritoneal dialysis patients. We demonstrate an important association between dialysis modality (HD vs CAPD) and higher FGF23, independent of classical determinants (serum calcium and phosphate level).

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Acknowledgements

The authors thank all staffs in Peritoneal Dialysis center and Hemodialysis center in Peking University 3rd Hospital for sample collection and all the people (healthy volunteers and patients) who participated in the study. This work was funded by The National Natural Science Funds in China (Project 81100522). An abstract was presented in poster form at the 15th Congress for the International Society for Peritoneal Dialysis (ISPD); September, 2014, Madrid, Spain.

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Authors and Affiliations

  1. Division of Nephrology, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, People’s Republic of China

    Shuhong Bi, Yaoxian Liang, Litao Cheng, Yue Wang, Tao Wang, Qinfeng Han & Aihua Zhang

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  1. Shuhong Bi
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  2. Yaoxian Liang
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  3. Litao Cheng
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  4. Yue Wang
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  5. Tao Wang
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  6. Qinfeng Han
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  7. Aihua Zhang
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Correspondence to Shuhong Bi.

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Conflict of interest

The authors have declared that they have no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Human Clinical Study Committee of Peking University Third Hospital.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Bi, S., Liang, Y., Cheng, L. et al. Hemodialysis is associated with higher serum FGF23 level when compared with peritoneal dialysis. Int Urol Nephrol 49, 1653–1659 (2017). https://doi.org/10.1007/s11255-017-1605-z

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  • DOI: https://doi.org/10.1007/s11255-017-1605-z

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