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Circulating FGF23 is not associated with cardiac dysfunction, atherosclerosis, infection or inflammation in hemodialysis patients

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Abstract

Fibroblast growth factor (FGF) 23 is a bone-derived hormone regulating serum inorganic phosphate (Pi) concentration. FGF23 is also involved in the development of chronic kidney disease (CKD)-mineral and bone disorder. Serum FGF23 concentration begins to increase early in the progression of CKD and can be remarkably high in hemodialysis patients with end-stage renal disease. It has been reported that high FGF23 concentration is a risk factor for cardiac dysfunction, atherosclerosis, infection or systemic inflammation in CKD patients. FGF23 was also shown to induce cardiac hypertrophy directly acting on cardiomyocytes. However, it is still controversial whether high FGF23 is causing cardiac dysfunction, atherosclerosis, infection or systemic inflammation in CKD patients. In the current study, we investigated whether FGF23 concentration is associated with cardiac dysfunction, atherosclerosis, infection or systemic inflammation in Japanese hemodialysis patients. We recruited 119 hemodialysis patients and examined the association between serum FGF23 concentration and several parameters concerning mineral metabolism, cardiac dysfunction, atherosclerosis, infection, and systemic inflammation. Serum FGF23 concentration was independently associated with serum calcium and Pi concentration (β = 0.276, p < 0.001; β = 0.689, p < 0.001). However, serum FGF23 concentration was not associated with parameters of cardiac dysfunction, atherosclerosis, infection, and systemic inflammation, either. Our results do not support the hypothesis that high FGF23 in dialysis patients is the cause of cardiac dysfunction, atherosclerosis, infection or systemic inflammation.

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Acknowledgements

The authors thank all staffs of Kawashima Hospital for giving us great support concerning recruiting patients and correcting data set.

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Authors and Affiliations

  1. Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan

    Yuichi Takashi, Masashi Ishizu, Akio Kuroda & Munehide Matsuhisa

  2. Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan

    Yuichi Takashi, Toshio Matsumoto & Seiji Fukumoto

  3. Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan

    Shu Wakino & Hitoshi Minakuchi

  4. Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan

    Masashi Ishizu

  5. Department of Kidney Disease, Kawashima Hospital, Tokushima, Japan

    Hisato Shima, Manabu Tashiro, Kazuyoshi Okada, Jun Minakuchi & Shu Kawashima

  6. Department of Internal Medicine, Kawashima Hospital, Tokushima, Japan

    Keiko Miya

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  1. Yuichi Takashi
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  2. Shu Wakino
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  14. Seiji Fukumoto
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Correspondence to Seiji Fukumoto.

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Takashi, Y., Wakino, S., Minakuchi, H. et al. Circulating FGF23 is not associated with cardiac dysfunction, atherosclerosis, infection or inflammation in hemodialysis patients. J Bone Miner Metab 38, 70–77 (2020). https://doi.org/10.1007/s00774-019-01027-7

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  • DOI: https://doi.org/10.1007/s00774-019-01027-7

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