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Peritoneal microvascular endothelial function and the microinflammatory state are associated with baseline peritoneal transport characteristics in uremic patients

  • Nephrology - Original Paper
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Abstract

Purpose

To investigate microvessel density (MVD), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and interleukin-6 (IL-6) mRNA expression in peritoneal tissues, and their relationships with baseline peritoneal transport in uremia.

Methods

Thirty uremic patients with a peritoneal dialysis catheter were selected in the Department of Nephrology in Dalian Central Hospital, Liaoning, China between 2010 and 2012. Peritoneal specimens were harvested for assessment of MVD, VEGF, eNOS, and IL-6 mRNA expression. One month after continuous ambulatory peritoneal dialysis, a peritoneal equilibration test was conducted. According to the 4-h peritoneal dialysate and plasma creatinine ratio (D/P Cr), patients were divided into high (n = 16) and low (n = 14) transport groups.

Results

General clinical data of high and low transport groups were similar (P > 0.05). The MVD in peritoneal tissues was significantly higher in the high than in the low transport group (P < 0.05). Correspondingly, VEGF (P < 0.01), eNOS (P < 0.01), and IL-6 (P < 0.05) mRNA expression levels were significantly higher in the high as compared the low transport groups. Correlation analysis showed that the baseline D/P Cr was positively correlated with MVD and VEGF, eNOS, and IL-6 mRNA expression levels in the peritoneum (r = 0.506, 0.646, 0.638, and 0.686, respectively; P < 0.01).

Conclusions

Uremic patients display differences in peritoneal microvascular endothelial function and microinflammatory states before peritoneal dialysis. Patients of the high transport group have higher MVD, increased expression of endothelial function markers (VEGF and eNOS), and the microinflammatory marker (IL-6). These observations are closely related to high baseline peritoneal transport.

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Acknowledgments

This study was supported by the project of Dalian Health Committee of the Liaoning Province (2011).

Conflict of interest

The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Nephrology, Dalian Central Hospital, Dalian, 116033, Liaoning, China

    Lanbo Teng, Ming Chang, Shuxin Liu, Min Niu, Yungang Zhang, Xiangfei Liu & Xiaoxia Yu

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  1. Lanbo Teng
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  2. Ming Chang
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  3. Shuxin Liu
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  4. Min Niu
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  5. Yungang Zhang
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  6. Xiangfei Liu
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Correspondence to Lanbo Teng.

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Lanbo Teng and Ming Chang are the co-first authors.

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Teng, L., Chang, M., Liu, S. et al. Peritoneal microvascular endothelial function and the microinflammatory state are associated with baseline peritoneal transport characteristics in uremic patients. Int Urol Nephrol 47, 191–199 (2015). https://doi.org/10.1007/s11255-014-0775-1

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  • DOI: https://doi.org/10.1007/s11255-014-0775-1

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