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Nickel(II) complexes of thiosemicarbazones: synthesis, characterization, X-ray crystallographic studies and in vitro antitubercular and antimicrobial studies

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Abstract

Three nickel(II) thiosemicarbazone complexes have been synthesized and characterized by spectroscopic and physicochemical techniques. The molecular structures of two of the complexes have been determined by single-crystal X-ray diffraction studies. In both of these complexes, the nickel center is coordinated by two tridentate ligands in a meridional fashion using C=S, C=N and neutral hydroxyl OH donors. The ligand is bound to nickel in its thione form in all three complexes. The synthesized compounds were tested for antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi. Additionally, all the compounds were screened for antituberculosis activity. Several complex/organism combinations returned an MIC value of 0.8 μg/mL or better, which is almost 8 times more active than the standard (streptomycin, 6.25 μg/mL).

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Acknowledgments

The authors thank USIC, Karnatak University, Dharwad, for providing spectral facilities. One of the authors (Sandeep P. Netalkar) is thankful to Department of Science and Technology for providing financial assistance under INSPIRE fellowship program.

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Authors and Affiliations

  1. Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad, 580 003, Karnataka, India

    Priya P. Netalkar, Sandeep P. Netalkar & Vidyanand K. Revankar

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  1. Priya P. Netalkar
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  2. Sandeep P. Netalkar
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  3. Vidyanand K. Revankar
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Correspondence to Vidyanand K. Revankar.

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Netalkar, P.P., Netalkar, S.P. & Revankar, V.K. Nickel(II) complexes of thiosemicarbazones: synthesis, characterization, X-ray crystallographic studies and in vitro antitubercular and antimicrobial studies. Transition Met Chem 39, 519–526 (2014). https://doi.org/10.1007/s11243-014-9827-8

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  • DOI: https://doi.org/10.1007/s11243-014-9827-8

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