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Phytochemicals as potential therapeutics for thrombocytopenia

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Abstract

Medical knowledge has always relied on plants as the main sources of important beneficial compounds. Many species have been recognized to have medicinal properties and beneficial impact on health, e.g. antioxidant activity, digestive stimulation action, anti-inflammatory, antimicrobial, hypolipidemic, antimutagenic and anticarcinogenic potential. This review focuses on the promising role of plants and their products in attenuating thrombocytopenia, a common and complex bleeding disorder. When the platelet count decreases below 150,000/µl, it causes thrombocytopenia. This bleeding disorder is observed in 2.5 % of the normal population. The risk of spontaneous muco-cutaneous bleeding and life threatening intracranial haemorrhage or gastrointestinal bleeding increases rapidly when the platelet count decreases below 10,000/µl. The inability to provide supportive treatment to increase the platelet counts often proves fatal to patients. Currently, treatment for thrombocytopenia includes use of drugs or splenectomy or platelet transfusions, in severe cases. Recently, studies have shown platelet augmenting activity of various plant extracts. The effectiveness, toxicity and side effects of the phytochemicals have to be critically evaluated in clinical trials. An in depth understanding of the role and mechanism of these phytochemicals would lead to their successful implementation in treatment and management of thrombocytopenia and other related bleeding disorders.

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References

  1. Kumar S, Malhotra R, Kumar D (2010) Euphorbia hirta: its chemistry, traditional and medicinal uses and pharmacological activities. Pharmacogn Rev 4:58–61

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Stef DS, Iosif G, Ioan-Trasca T, Stef L, Pop C, Harmanescu M, Biron R, Pet E (2010) Evaluation of 33 medicinal plant extracts for the antioxidant capacity and total phenols. J Food Agric Environ 8:207–210

    Google Scholar 

  3. Wojdylo A, Oszmianski J, Czemerys R (2007) Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chem 105:940–949

    Article  CAS  Google Scholar 

  4. Yildiz L, Baskan KS, Tutem E, Apak R (2008) Combined HPLC-CUPRAC (cupric ion reducing antioxidant capacity) assay of parsley, celery leaves, and nettle. Talanta 77:304–313

    Article  CAS  PubMed  Google Scholar 

  5. Stiff PJ (1990) Clinical methods: the history, physical and laboratory examinations. In: Walker HK, Hall WD, Hurst JW (eds) The origins of the history and physical examination. Butterworths, Boston

    Google Scholar 

  6. Sekhon SS, Roy V (2006) Thrombocytopenia in adults: a practical approach to evaluation and management. South Med J 99:491–498

    Article  PubMed  Google Scholar 

  7. Erkurt MA, Kaya E, Berber I, Koroglu M, Kuku I (2012) Thrombocytopenia in adults: review article. J Hematol 1:44–53

    CAS  Google Scholar 

  8. Sandler SG, Tutuncuoglu SO (2004) Immune thrombocytopenic purpura—current management practices. Expert Opin Pharmacother 5:2515–2527

    Article  CAS  PubMed  Google Scholar 

  9. Scaradavou A, Woo B, Woloski BMR, Cunningham-Rundles S, Ettinger LJ, Aledort LM, Bussel JB (1997) Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients. Blood 89:2689–2700

    CAS  PubMed  Google Scholar 

  10. Warrier R, Chauhan A (2012) Management of immune thrombocytopenic purpura: an update. Ochsner J 12:221–227

    PubMed  PubMed Central  Google Scholar 

  11. Zaja F, Battista ML, Pirrotta MT, Palmieri S, Montagna M, Vianelli N, Marin L, Cavallin M, Bocchia M, Defina M, Ippoliti M, Ferrara F, Patriarca F, Avanzini MA, Regazzi M, Baccarani M, Isola M, Soldano F, Fanin R (2008) Lower dose rituximab is active in adults patients with idiopathic thrombocytopenic purpura. Haematologica 93:930–933

    Article  CAS  PubMed  Google Scholar 

  12. Ghanima W, Godeau B, Cines DB, Bussel JB (2012) How I treat immune thrombocytopenia (ITP): the choice between splenectomy or a medical therapy as a second-line treatment. Blood 120:960–969

    Article  CAS  PubMed  Google Scholar 

  13. Arollado EC, Pena IG, Dahilig VRA (2013) Platelet augmentation activity of selected Philippine plants. Int J Pharm Phytopharmacol Res 3:121–123

    Google Scholar 

  14. Dharmarathna SLCA, Wickramasinghe S, Waduge RN, Rajapakse RPVJ, Kularatne SAM (2013) Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model. Asian Pac J Trop Biomed 3:720–724

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Stivala S, Reiner MF, Lohmann C, Luscher TF, Matter CM, Beer JH (2013) Dietary α-linolenic acid increases the platelet count in ApoE −/− mice by reducing clearance. Blood 122:1026–1033

    Article  CAS  PubMed  Google Scholar 

  16. Apostol JG, Gan JVA, Raynes RJB, Sabado AAS, Carigma AQ, Santiago LA, Ysrael MC (2012) Platelet-increasing effects of Euphorbia hirta Linn. (Euphorbiaceae) in ethanol-induced thrombocytopenic rat models. Int J Pharm Front Res 2:1–11

    Google Scholar 

  17. Abrokwah FK, Asamoah KA, Esubonteng PKA (2009) Effects of the intake of natural cocoa powder on some biochemical and haematological indices in the rat. Ghana Med J 43:164–168

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Patil S, Shetty S, Bhide R, Narayanan S (2013) Evaluation of platelet augmentation activity of Carica papaya leaf aqueous extract in rats. J Pharmacogn Phytochem 1:57–60

    Google Scholar 

  19. Mosa RA, Lazarus GG, Gwala PE, Oyedeji AO, Opoku AR (2011) In vitro anti-platelet aggregation, antioxidant and cytotoxic activity of extracts of some Zulu medicinal plants. J Nat Prod 4:136–146

    Google Scholar 

  20. Policegoudra RS, Chandrashekhar RH, Aradhya SM, Singh L (2011) Cytotoxicity, platelet aggregation inhibitory and antioxidant activity of Curcuma amada Roxb. extracts. Food Technol Biotech 49:162–168

    Google Scholar 

  21. Mary NK, Achuthan CR, Babu BH, Padikkala J (2003) In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L). J Ethnopharmacol 87:187–191

    Article  CAS  PubMed  Google Scholar 

  22. Sumitra M, Manikandan P, Kumar DA, Arutselvan N, Balakrishna K, Manohar MB, Puvanakrishnan R (2001) Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status. Mol Cell Biochem 224:135–142

    Article  CAS  PubMed  Google Scholar 

  23. Subenthiran S, Choon TC, Cheong KC, Thayan R, Teck MB, Muniandy PK, Afzan A, Abdullah NR, Ismail Z (2013) Carica papaya leaves juice significantly accelerates the rate of increase in platelet count among patients with dengue fever and dengue haemorrhagic fever. Evid Based Complement Altern Med. doi:10.1155/2013/616737

    Google Scholar 

  24. Jubelirer SJ (1993) Pilot study of ascorbic acid for the treatment of refractory immune thrombocytopenic purpura. Am J Hematol 43:44–46

    Article  CAS  PubMed  Google Scholar 

  25. Brox AG, Howson-Jan K, Fauser AA (1988) Treatment of idiopathic thrombocytopenic purpura with ascorbate. Br J Haematol 70:341–344

    Article  CAS  PubMed  Google Scholar 

  26. Chandra P, Sharma H, Gupta A, Rai Y (2013) Role of antioxidant vitamin E and C on platelet levels in dengue fever. Int J Basic Appl Med Sci 3:287–291

    Google Scholar 

  27. Dutta TK, Goel A, Ghotekar LH, Hamide A, Badhe BA, Basu D (2001) Dapsone in treatment of chronic idiopathic thrombocytopenic purpura in adults. J Assoc Physicians India 49:421–425

    CAS  PubMed  Google Scholar 

  28. Rein D, Paglieroni TG, Wun T, Pearson DA, Schmitz HH, Gosselin R, Keen CL (2000) Cocoa inhibits platelet activation and function. Am J Clin Nutr 72:30–35

    CAS  PubMed  Google Scholar 

  29. Bickford PC, Tan J, Shytle D, Sanberg CD, El-Badri N, Sanberg PR (2006) Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev 15:118–123

    Article  CAS  PubMed  Google Scholar 

  30. Tahir N, Zaheer Z, Kausar S, Chiragh S (2014) Prevention of fall in platelet count by Carica papaya leaf juice in carboplatin induced thrombocytopaenia in mice. Biomedica 30:21–25

    Google Scholar 

  31. Patel SR, Hartwig JH, Italiano JE (2005) The biosynthesis of platelet from megakaryocyte proplatelets. J Clin Investig 115:3348–3354

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Jigna P, Nehal L, Sumithra C (2006) Evaluation of antibacterial and phytochemical analysis of Bauhinia variegate L. bark. Afr J Biomed Res 9:53–56

    Google Scholar 

  33. Ranasinghe P, Ranasinghe P, Abeysekera WP, Premakumara GA, Perera YS, Gurugama P, Gunatilake SB (2012) In vitro erythrocyte membrane stabilizing properties of Carica papaya L. leaf extracts. Pharm Res 4:196–202

    Google Scholar 

  34. Hiermann A, Bucar F (1986) Influence of some traditional medicinal plants of Senegal on prostaglandin biosynthesis. J Ethnopharmacol 42:111–116

    Article  Google Scholar 

  35. Gupta R (1966) A chemical examination of Euphorbia hirta Linn. Bull Chem Soc Japan 39:2532–2534

    Article  CAS  Google Scholar 

  36. Blanc P, Bertrand P, Plantes G (1972) Flavanoids of Euphobia hirta. Med Phytother 6:106–109

    CAS  Google Scholar 

  37. Aqil Euphorbianin M (1999) A new glycoside from Euphorbia hirta Linn. Global J Pure Appl Sci 5:371

    Google Scholar 

  38. Chen L (1991) Polyphenols from leaves of Euphorbia hirta L. Zhongguo Zhong Yao Za Zhi 16:38–39

    CAS  PubMed  Google Scholar 

  39. Joseph GV, Drangari V (2002) Standardisation and quality evaluation of Euphorbin nivulia Buch.ham. Anc Sci Life 21:160–166

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Yoshida T, Namba O, Okuda T (1989) Hydrolysable tannin oligomers from Euphorbiaceae. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 31:601

    Google Scholar 

  41. Martinez-Vazquez M, Apan TOR, Lazcano ME, Bye R (1999) Anti-inflammatory active components from n-hexane extract of Euphorbia hirta. Rev Soc Quim Mexico 43:103–105

    CAS  Google Scholar 

  42. Wang J, Xu J, Zhong J (2004) Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patient with blood hyperviscosity syndrome. Zhingguo Zhong Xi Yi Jie He ZaZhi 24:312–316

    Google Scholar 

  43. Kativar C, Gupta A, Kaniilal S, Kativar S (2012) Drug discovery from plant sources: an integrated approach. Ayu 33:10–19

    Article  Google Scholar 

  44. Kidd PM (2009) Bioavailbility and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea and grape seed extracts. Altern Med Rev 14:226–246

    PubMed  Google Scholar 

  45. Musthaba SM, Sayeed A, Alka A, Javed A (2009) Nano approaches to enhance pharmacokinetic and pharmacodynamic activity of plant origin drugs. Curr Nanosci 5:344–352

    Article  CAS  Google Scholar 

  46. Kumar A, Nasair AG, Reddy AV, Garg AN (2006) Bhasmas: unique ayurvedic metallic-herbal preparations, chemical characterization. J Biol Trace Element Res 109:231–254

    Article  CAS  Google Scholar 

  47. Lahlou M (2012) De la plante au medicament: Une passerelle entre tradition et science. Maroc, p 272

  48. Fabrican DS, Farnsworth NR (2001) The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 109:69–75

    Article  Google Scholar 

  49. Doughari JH, Human IS, Bennade S, Ndakidemi PA (2009) Phytochemicals as chemotherapeutic agents and antioxidants: possible solution to the control of antibiotic resistant verocytotoxin producing bacteria. J Med Plants Res 3:839–848

    CAS  Google Scholar 

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Acknowledgments

The authors acknowledge Dr. Leela Iyengar, Mr. Carl Hsieh and Jain University for their support.

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Authors and Affiliations

  1. Department of Biotechnology, Center for Post Graduate Studies, Jain University, #18/3, 9th Main, 3rd Block, Jayanagar, Bangalore, 560011, India

    K. Manasa, R. Soumya & R. Vani

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  1. K. Manasa
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  2. R. Soumya
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  3. R. Vani
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Correspondence to R. Vani.

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Manasa, K., Soumya, R. & Vani, R. Phytochemicals as potential therapeutics for thrombocytopenia. J Thromb Thrombolysis 41, 436–440 (2016). https://doi.org/10.1007/s11239-015-1257-8

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  • DOI: https://doi.org/10.1007/s11239-015-1257-8

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