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Engineering delivery of pantaprazole drug using multi-walled carbon nanotubes: an experimental and theoretical study

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Abstract

Todays, using nano-based drug delivery systems as suitable carriers can help in controlling release of drug to target cells. In current study, multi-walled carbon nanotube (MWCNTs) have been proposed as a suitable carrier (adsorbent) for improvement of pantoprazole (PTZ) drug delivery. The PTZ adsorption on the MWCNT has been assayed using three well-known Langmuir, Freundlich, and Temkin isotherm models. High value of isotherm constant (KL = 0.143 L mg−1) and low separation factor (RL = 0.24) imply strong and desirable adsorption of the PTZ on the MWCNT with 1.00 mg L−1 concentration at 298-K temperature and acidic medium, pH = 6.0. More importantly, decreasing the PTZ adsorption and dehydrogenation mainly result from increasing pH factor. Negative thermodynamic parameter such as ΔH =  − 6.31 kJ mol−1 based on Van’t Hoff equation shows that the PTZ adsorption has fast kinetic in pseudo-second-order kinetic model (R2 = 1.00) and exothermic processes at 25 min. In density functional theory framework, high global softness (0.24 eV) of the PTZ and more negative adsorption energy (− 6.02 kJ mol−1) reveal that this compound transfers by using MWCNT. These issues imply that MWCNT is suitable carrier in order to control release of the PTZ drug to target cells without side effects.

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Acknowledgements

The authors gratefully thank Dr. Fazlolah Eshghi for his suggestions and help in this study.

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Authors and Affiliations

  1. Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran

    Neda Sadeghpour & Narges Bagheri

  2. Department of Chemistry, Fasa Branch, Islamic Azad University, Fasa, Iran

    Mahdi Vadi

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  1. Neda Sadeghpour
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  2. Mahdi Vadi
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  3. Narges Bagheri
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Contributions

Mehdi Vadi conceived of the presented idea. Neda Sadeghpour carried out computational jobs and experiments. Neda Sadeghpour and Narges Bagheri wrote the manuscript and discussed the results and contributed to the final manuscript.

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Correspondence to Mahdi Vadi.

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Sadeghpour, N., Vadi, M. & Bagheri, N. Engineering delivery of pantaprazole drug using multi-walled carbon nanotubes: an experimental and theoretical study. Struct Chem 33, 733–742 (2022). https://doi.org/10.1007/s11224-022-01883-6

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