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Synthesis and studies of antimicrobial activity of azomethine crown ether derivatives and their copper complexes

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Abstract

New Schiff bases were synthesized by condensation of 4-pyridinecarboxaldehyde with crown ethers (4-aminobenzo-15-crown-5, 4,4-diaminodibenzo-18-crown-6, and 4,4-diaminodibenzo-21-crown-7). Treatment of the synthesized azomethines with equimolar amount of copper(II) acetate gave the corresponding copper complexes. Antimicrobial activity of crown ethers and their derivatives against Gram-positive (Staphylococcus aureus, Micrococcus luteus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria was studied. The effects of the substituents on antimicrobial activity of the ligands and their derivatives were analyzed.

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Funding

Analytical studies were performed with the use of the scientific equipment of the Center for Collective Use of National Research Centre “Kurchatov Institute” — IREA with the financial support from the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-11-2021-070 dated 19.08.2021).

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Authors and Affiliations

  1. Institute of Chemical Reagents and High Purity Chemical Substances of National Research Centre “Kurchatov Institute”, 3 ul. Bogorodskii Val, 107076, Moscow, Russian Federation

    N. Yu. Sadovskaya, V. N. Glushko, L. I. Blokhina, S. K. Belus’ & V. M. Retivov

  2. National Research Centre “Kurchatov Institute”, 1 pl. Akad. Kurchatova, 123182, Moscow, Russian Federation

    V. M. Retivov

  3. State Scientific Center “NIOPIK”, 7 Likhachevskii proezd, 141701, Dolgoprudnyi, Moscow Region, Russian Federation

    M. Yu. Zhila

  4. Lomonosov Moscow State University, 1 ul. Kolmogorova, 119991, Moscow, Russian Federation

    T. A. Cherdynceva

Authors
  1. N. Yu. Sadovskaya
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  2. V. N. Glushko
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  3. L. I. Blokhina
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  4. S. K. Belus’
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  5. V. M. Retivov
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  6. M. Yu. Zhila
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  7. T. A. Cherdynceva
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Corresponding authors

Correspondence to N. Yu. Sadovskaya, V. M. Retivov, M. Yu. Zhila or T. A. Cherdynceva.

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No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1300–1304, June, 2022.

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Sadovskaya, N.Y., Glushko, V.N., Blokhina, L.I. et al. Synthesis and studies of antimicrobial activity of azomethine crown ether derivatives and their copper complexes. Russ Chem Bull 71, 1300–1304 (2022). https://doi.org/10.1007/s11172-022-3534-y

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  • DOI: https://doi.org/10.1007/s11172-022-3534-y

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