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Prospects for the inhibition of the phosphatase domain of human soluble epoxide hydrolase (sEH-P)

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Abstract

This brief review highlights the history of the discovery of the phosphatase domain of human soluble epoxide hydrolase (sEH-P). The data on its structure and physiological role are summarized. State-of-the-art methods for the evaluation of the inhibitory activity of small molecules against sEH-P are described. The structures of endogenous substrates and known inhibitors of sEH-P are considered. The prospects of the development of this area of research in medicinal chemistry are analyzed.

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Authors and Affiliations

  1. Volgograd State Technical University, 28 prosp. Lenina, 400005, Volgograd, Russian Federation

    V. V. Burmistrov, G. M. Butov & I. A. Novakov

  2. Skolkovo Institute of Science and Technology, 1 Build., 30 Bolshoy bulevard, 121205, Moscow, Russian Federation

    D. S. Karlov

  3. Volzhsky Polytechnic Institute (branch) of Volgograd State Technical University, 42a ul. Engelsa, 404121, Volzhsky, Volgograd Region, Russian Federation

    G. M. Butov

Authors
  1. V. V. Burmistrov
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  2. D. S. Karlov
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  3. G. M. Butov
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  4. I. A. Novakov
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Correspondence to G. M. Butov.

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Dedicated to Academician of the Russian Academy of Sciences V. N. Charushin on the occasion of his 70th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1067–1074, June, 2021.

This work was financially supported by the Russian Foundation for Basic Research (Project No. 20-03-00298).

No human or animal subjects were involved in this research.

The authors declare no conflict of interest, financial or otherwise.

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Burmistrov, V.V., Karlov, D.S., Butov, G.M. et al. Prospects for the inhibition of the phosphatase domain of human soluble epoxide hydrolase (sEH-P). Russ Chem Bull 70, 1067–1074 (2021). https://doi.org/10.1007/s11172-021-3185-4

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  • DOI: https://doi.org/10.1007/s11172-021-3185-4

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