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Specific features of radical generation in the reaction of thiols with hydrogen peroxide

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Abstract

Using the method of inhibitors it was found that the reduction of H2O2 with natural thiols in aqueous solutions is accompanied by the formation of radicals. The reaction of the nitroxyl radical TEMPO with glutathione (GSH) and H2O2 was studied together and separately. It allowed us to determine the optimal conditions for using the spin trap method in the presence of thiols. In the case of 5,5′-dimethyl-1-pyrroline N-oxide the reaction of GSH and synthetic thiol N-acetylcysteine with hydrogen peroxide at pH < 7 leads to the formation of thiyl and hydroxyl radicals.

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Authors and Affiliations

  1. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119991, Moscow, Russian Federation

    K. M. Zinatullina, O. T. Kasaikina, M. V. Motyakin, I. S. Ionova & E. N. Degtyarev

  2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119991, Moscow, Russian Federation

    M. V. Motyakin, E. N. Degtyarev & N. P. Khrameeva

Authors
  1. K. M. Zinatullina
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  2. O. T. Kasaikina
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  3. M. V. Motyakin
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  4. I. S. Ionova
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  5. E. N. Degtyarev
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  6. N. P. Khrameeva
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Correspondence to K. M. Zinatullina.

Additional information

This work was financially supported by the Russian Foundation for Basic Research (Project Nos 18-33-00742 and 20-03-00753) and in the framework of the state assignment of the Russian Federal Agency for Scientific Organizations (FASO) (Project No. 0082-2018-0006, reg. No. AAAA-A18-118020890097-1).

Russian Chemical Bulletin, International Edition, Vol. 69, No. 10, pp. 1865–1868, October, 2020

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1865–1868, October, 2020.

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Zinatullina, K.M., Kasaikina, O.T., Motyakin, M.V. et al. Specific features of radical generation in the reaction of thiols with hydrogen peroxide. Russ Chem Bull 69, 1865–1868 (2020). https://doi.org/10.1007/s11172-020-2971-8

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  • DOI: https://doi.org/10.1007/s11172-020-2971-8

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