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Methyl (5-oxopyrazol-3-yl)acetate N,S-ketene acetal as a new building block for the construction of pyrazolo[4,3-c]pyridines

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Abstract

Methyl (5-oxopyrazol-3-yl)acetate is added to methylthiocyanate C≡N bond in the presence of Ni(OAc)2 giving a corresponding heterocyclic N,S-ketene acetal. The latter compound was used as a convenient synthon in the synthesis of new pyrazolo[4,3-c]pyridin-3-ones and pyrazolo[4,3-c]pyridine-3,6-diones.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    M. A. Prezent, S. V. Ruban, S. V. Baranin & Yu. N. Bubnov

Authors
  1. M. A. Prezent
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  2. S. V. Ruban
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  3. S. V. Baranin
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  4. Yu. N. Bubnov
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Corresponding author

Correspondence to S. V. Baranin.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 1004—1007, April, 2016.

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Prezent, M.A., Ruban, S.V., Baranin, S.V. et al. Methyl (5-oxopyrazol-3-yl)acetate N,S-ketene acetal as a new building block for the construction of pyrazolo[4,3-c]pyridines. Russ Chem Bull 65, 1004–1007 (2016). https://doi.org/10.1007/s11172-016-1403-2

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  • DOI: https://doi.org/10.1007/s11172-016-1403-2

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