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Identification and quantitative determination of active pharmaceutical ingredients in suppositories by a combination of 1H NMR spectroscopy and desorption mass spectrometry

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Abstract

A fast, highly sensitive, and precise procedure was proposed for the identification and determination of the composition of suppositories, which are dosage forms of drugs in a lipophilic base, using a combination of quantitative 1H NMR spectroscopy and desorption mass spectrometry methods.

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References

  1. G. A. Kalabin, L. V. Kanitskaya, D. F. Kushnarev, Kolichestvennaya spektroskopiya YaMR prirodnogo organicheskogo syr’ya i produktov ego pererabotki [Quantitative NMR Spectroscopy of Organic Raw Materials and Products of Its Processing], Khimiya, Moscow, 2000, 408 pp. (in Russian).

    Google Scholar 

  2. B. King, Accredit. Qual. Assur., 2000, 5, 429.

    Article  CAS  Google Scholar 

  3. S. K. Bharti, R. Roy, Trends Anal. Chem., 2012, 35, 5.

    Article  CAS  Google Scholar 

  4. U. Holzgrabe, Prog. Nucl. Magn. Reson. Spectr., 2010, 57, 229.

    Article  CAS  Google Scholar 

  5. Gosudarstvennaya Farmakopeya Rossiiskoi Federatsii [State Pharmacopoeia of the Russian Federation], XII Ed., p. 1, Nauchnyi tsentr ekspertizy sredstv meditsinskogo primeneniya, Moscow, 2008, 73 (in Russian).

  6. USP 29/NF 24, U. S. Pharmacopeial Convention, Rockville, Maryland, 2006, 3539 pp.

  7. R. G. Glushkov, V. A. Maksimov, V. A. Mart’yanov, R. A. Khamitov, A. M. Shuster, Pat. No. RU 2 255 086 C1 (RF), http://bd.patent.su/2255000-2255999/pat/servl/servletee8a.html.

  8. R. A. Abramovich, S. V. Goryainov, A. N. Vorob’ev, G. A. Kalabin, Voprosy Biol. Med. Farm. Khim. [Problems Biol., Med. and Pharm. Chem.], 2012, 9, 13 (in Russian).

    Google Scholar 

  9. V. S. Kartashov, Voprosy Biol. Med. Farm. Khim. [Problems Biol., Med. and Pharm. Chem.], 2001, 4, 38 (in Russian).

    Google Scholar 

  10. V. V. Lebedev, V. I. Pokrovskii, T. M. Shelepova, O. G. Stepanov; Pat. No. RU (11) 2062096 (13) C, http://www.findpatent.ru/patent/206/2062096.html.

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Authors and Affiliations

  1. Peoples’ Friendship University of Russia, 6 ul. Miklukho-Maklaya, 117198, Moscow, Russian Federation

    G. A. Kalabin, S. V. Goryainov, V. A. Ivlev, F. Yu. Niftullaev & R. A. Abramovich

Authors
  1. G. A. Kalabin
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  2. S. V. Goryainov
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  3. V. A. Ivlev
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  4. F. Yu. Niftullaev
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  5. R. A. Abramovich
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Corresponding author

Correspondence to G. A. Kalabin.

Additional information

Based on materials of the XI International Workshop on Magnetic Resonance (Spectroscopy, Tomography, and Ecology) (September 9–14, 2013, Rostov-on-Don).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1848–1855, August, 2014.

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Kalabin, G.A., Goryainov, S.V., Ivlev, V.A. et al. Identification and quantitative determination of active pharmaceutical ingredients in suppositories by a combination of 1H NMR spectroscopy and desorption mass spectrometry. Russ Chem Bull 63, 1848–1855 (2014). https://doi.org/10.1007/s11172-014-0675-7

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  • DOI: https://doi.org/10.1007/s11172-014-0675-7

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