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Sonodynamic therapy of cancer. A comprehensive experimental study

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Abstract

Sonodynamic therapy in combination with antitumor drugs and sonosensitizers (theraphthal and its derivatives) was studied in preclinical testing against malignant tumors. The use of this therapy scheme enhances the destructive effect of ultrasound on tumors, promotes no metastasis, and make therapeutic drugs more bioavailable. The scheme was recommended for clinical use. A solid-phase sonosensitization mechanism was proposed. A possible system of laboratory and in vitro testing for selection of efficient sonosensitizers was outlined.

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Authors and Affiliations

  1. Department of Chemistry, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    A. L. Nikolaev, A. V. Gopin, V. E. Bozhevolnov, S. E. Mazina, A. V. Severin & V. N. Rudin

  2. N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, 23 Kashirskoe sh., 115478, Moscow, Russian Federation

    N. V. Andronova & H. M. Treschalina

  3. Research Institute of Intermediates and Dyes, 1 ul. Bol’shaya Sadovaya, 123995, Moscow, Russian Federation

    O. L. Kaliya, L. I. Solovyeva & E. A. Lukyanets

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  1. A. L. Nikolaev
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  2. A. V. Gopin
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  7. N. V. Andronova
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  8. H. M. Treschalina
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  9. O. L. Kaliya
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  10. L. I. Solovyeva
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  11. E. A. Lukyanets
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Corresponding author

Correspondence to A. L. Nikolaev.

Additional information

Based on the materials of the First Russian Conference on Medicinal Chemistry (“MedChem Russia-2013”) with International Participation (September 8–12, 2013, Moscow).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1036–1048, May, 2014.

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Nikolaev, A.L., Gopin, A.V., Bozhevolnov, V.E. et al. Sonodynamic therapy of cancer. A comprehensive experimental study. Russ Chem Bull 63, 1036–1047 (2014). https://doi.org/10.1007/s11172-014-0546-2

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  • DOI: https://doi.org/10.1007/s11172-014-0546-2

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