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Controlled delivery of tetracycline with TiO2@Chitosan@ZIF-8 nanocomposite and evaluation of their antimicrobial activities

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Abstract

In recent years, metal–organic frameworks (MOFs) have attracted the attention of scientists. The applications of these frameworks are gas storage and separation, electrochemical energy storage, drug delivery, catalyst, etc. In this research, a nanocarrier named TiO2@Chitosan@ZIF-8 was synthesized to deliver the antibiotic tetracycline (TC). Furthermore, the antimicrobial effect of TiO2@Chitosan@ZIF-8@TC was tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria with the best results. The structure of the nanocarrier, as well as the nanocarrier/drug, was validated by the X-ray crystallography (XRD), Fourier-transform infrared spectroscopy (FT-IR), Breuer–Emmett–Teller (BET), field emission scanning electron microscope (FE-SEM), Transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), and energy-dispersive X-ray spectroscopy (EDX/Mapping). This research indicated that 90% of the TC was encapsulated in the synthesized framework. Also, drug release was performed at pH: 5 and pH: 7.4, which revealed that 73% and 67% of TC were released in three days. It is considerable that this is the first report of the synthesizing and using a novel nanocarrier including TiO2@Chitosan@ZIF-8 with various advantages such as high surface area, high porosity, high loading percentage, and high stability.

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Acknowledgements

The present research was supported by Islamic Azad University, Qom Branch, Qom, Iran, based on grant number (2019-2898).

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Authors and Affiliations

  1. Department of Chemistry, Islamic Azad University, Qom Branch, Qom, Iran

    Mahdiyeh Akbari, Mohammad Emad Sadeghi & Mohammad Ali Ghasemzadeh

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  1. Mahdiyeh Akbari
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  2. Mohammad Emad Sadeghi
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  3. Mohammad Ali Ghasemzadeh
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Correspondence to Mohammad Ali Ghasemzadeh.

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Akbari, M., Sadeghi, M.E. & Ghasemzadeh, M.A. Controlled delivery of tetracycline with TiO2@Chitosan@ZIF-8 nanocomposite and evaluation of their antimicrobial activities. Res Chem Intermed 48, 3971–3985 (2022). https://doi.org/10.1007/s11164-022-04782-x

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