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2-Acetylphenothiazines as synthon in heterocyclic synthesis

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Abstract

This review presents a systematic and comprehensive survey of the method of preparation and the chemical reactivity of 2-acetylphenothiazines. The target compounds are important intermediates for the synthesis of a variety of synthetically useful and novel heterocyclic systems with different ring sizes such as isoxazole, pyrazole, pyrimidine, pyridine, quinolone, pyrazolo[3,4-d] pyridazine, 1,5-benzothiazepine, and triazolo[1,5-a] pyridine.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, 35516, Egypt

    Moustafa A. Gouda, Wafaa S. Hamama, Hadwah A. Kamal El-din & Hanafi H. Zoorob

  2. Department of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, Kingdom of Saudi Arabia

    Moustafa A. Gouda

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  1. Moustafa A. Gouda
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Correspondence to Wafaa S. Hamama.

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Gouda, M.A., Hamama, W.S., Kamal El-din, H.A. et al. 2-Acetylphenothiazines as synthon in heterocyclic synthesis. Res Chem Intermed 42, 6143–6162 (2016). https://doi.org/10.1007/s11164-016-2450-x

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