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1, 3-Disulfonic acid imidazolium hydrogen sulphate as an efficient and reusable ionic liquid for the multicomponent synthesis of polyhydroquinoline derivatives under solvent-free conditions

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Abstract

A facile and highly effective one-pot synthesis of polyhydroquinoline derivatives is reported via Hantzsch condensation of aldehydes, 1,3-dicarbonyl compounds, ethyl acetoacetate, and ammonium acetate in the presence of 1,3-disulfonic acid imidazolium hydrogen sulfate as an efficient and recyclable ionic liquid under solvent-free conditions. This methodology offers several advantages such as short reaction times, high yields, environmentally benign, mild reaction conditions, simple work-up procedure, and reusability of the ionic liquid.

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Acknowledgments

The authors acknowledge financial support for this work from the Iran National Science Foundation (INSF) (Grant Number 93014856) and partial support of this work by the Research Council of the University of Guilan. F. Shirini and K. Mohammadi also wish to thank the Sobhandarou Company for the partial facilities.

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Authors and Affiliations

  1. Department of Chemistry, College of Science, University of Guilan, Post Box: 1914, 41335, Rasht, I.R. Iran

    Kamal Mohammadi, Farhad Shirini & Asieh Yahyazadeh

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  1. Kamal Mohammadi
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  2. Farhad Shirini
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  3. Asieh Yahyazadeh
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Correspondence to Farhad Shirini or Asieh Yahyazadeh.

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Mohammadi, K., Shirini, F. & Yahyazadeh, A. 1, 3-Disulfonic acid imidazolium hydrogen sulphate as an efficient and reusable ionic liquid for the multicomponent synthesis of polyhydroquinoline derivatives under solvent-free conditions. Res Chem Intermed 42, 2047–2054 (2016). https://doi.org/10.1007/s11164-015-2134-y

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