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β-Cyclodextrine-SO3H: the most efficient catalyst for one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions

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Abstract

An environmentally benign and efficient method has been developed for the synthesis of a series of 2H-indazolo[2,1-b]phthalazine-triones derivatives with β-cyclodextrine-SO3H as a recyclable catalyst by simply combining of various aldehydes with cyclic 1,3-diketones and phthalhydrazide under solvent free condition. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, convergence, and facile automation.

Graphical Abstract

A greener, efficient, and expeditious method has been developed for the synthesis of 2H-indazolo [2,1-b] phthalazine-triones derivatives with β-cyclodextrine-SO3H as a recyclable catalyst for the first time.

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Acknowledgments

This research work was supported by the BK 21 plus program.

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Authors and Affiliations

  1. Department of Image Science and Engineering, Pukyong National University, Busan, 608-737, Republic of Korea

    Amol B. Atar, Sang Dong Lee, Byung Gwon Cho & Yeon Tae Jeong

  2. Department of Chemistry, Yeungnam University, Gyeongsan, Gyeongbuk, 712-749, Republic of Korea

    Amol B. Atar & Dae Won Cho

Authors
  1. Amol B. Atar
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  2. Sang Dong Lee
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  3. Byung Gwon Cho
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  4. Dae Won Cho
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  5. Yeon Tae Jeong
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Correspondence to Yeon Tae Jeong.

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Atar, A.B., Lee, S.D., Cho, B.G. et al. β-Cyclodextrine-SO3H: the most efficient catalyst for one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-triones under solvent-free conditions. Res Chem Intermed 42, 1707–1728 (2016). https://doi.org/10.1007/s11164-015-2113-3

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