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Health-related quality of life in patients with extremity bone sarcoma after surgical treatment: a systematic review

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Abstract

Purpose

We conducted a systematic review of studies reporting on measurement of health-related quality of life (HRQoL), with a special focus on the use of the preference-weighted instruments, in patients with extremity bone sarcoma treated with limb-salvage surgery or amputation.

Methods

We searched MedLine, Embase, Cochrane Library and Web of Science for English-language studies reporting on HRQoL of patients with bone sarcoma from inception to 28 August 2023. All records found were independently reviewed by two reviewers. We used the Newcastle–Ottawa Scale (NOS) and the CONSORT 2010 checklist to assess the quality of the cohort and randomised studies, respectively.

Results

The search identified 1225 records, of which 16 studies were included for data extraction. Only one study used a preference-weighted instrument for measuring HRQoL in a small sample of patients (n = 28). Ten studies used the generic SF-36 questionnaire, but no preference-weighted HRQoL based on SF-6D was derived from the SF-36 scores. Most studies comparing HRQoL between amputation and limb-salvage surgery reported no significant differences. Twelve cohort studies scored six or more out of nine points based on the NOS. The only randomised study scored 54% on the CONSORT 2010 checklist.

Conclusions

The approaches used to measure HRQoL were inconsistent and outcome scores varied substantially. Only one study used preference-weighted instruments for HRQoL measurement. Future research into the surgical treatment of extremity bone sarcoma should consider the use of preference-weighted instruments to measure HRQoL, which will therefore enable economic evaluation for the growing orthopaedic armamentarium of novel surgical interventions.

Registration

This systematic review was registered with the PROSPERO International prospective register of systematic reviews (CRD42021282380).

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Data availability

Not applicable. All data have been presented in the paper.

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Funding

This study was partly funded by the Innovative Manufacturing Cooperative Research Centre (IMCRC). IMCRC had no role in the design or conduct of the study, the collection, management, analyses, and interpretation of the data, or the preparation and review of the manuscript. An Tran-Duy is partly supported by the Methods and Implementation Support for Clinical and Health research (MISCH) Hub at the University of Melbourne.

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  1. Centre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia

    Liam Fernando-Canavan, Patrick Abraham, Nancy Devlin & An Tran-Duy

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  1. Liam Fernando-Canavan
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Contributions

Conceptualisation: AT-D; Methodology: AT-D and ND; Literature search and data extraction: LF-C and PA; Formal analysis and Investigation: All authors; Visualisation: AT-D and LF-C; Writing—original draft: LF-C and AT-D; Writing—review & editing: All authors; Funding acquisition: ND and AT-D; Supervision: AT-D.

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Correspondence to An Tran-Duy.

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Fernando-Canavan, L., Abraham, P., Devlin, N. et al. Health-related quality of life in patients with extremity bone sarcoma after surgical treatment: a systematic review. Qual Life Res 33, 1157–1174 (2024). https://doi.org/10.1007/s11136-023-03554-3

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