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Health-related quality of life in women referred for bone density assessment: relationships with bone mineral density, fracture and co-morbidity

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Abstract

Purpose

To identify variables that might influence health-related quality of life (HRQoL) in patients with and without a history of fracture, attending bone mineral density (BMD) assessment prior to diagnosis of osteoporosis.

Methods

This cross-sectional study included 312 newly referred postmenopausal women attending for a DXA scan, without a diagnosis of osteoporosis. Data were obtained from the medical history and the General Practitioner’s letter. HRQoL, using SF36 was scored using published algorithms with reference to an age-related population from England. Regression analyses were used to determine relationships between HRQoL and BMD, age, fracture status and co-morbidities.

Results

For all patients, the age-related physical component summary (PCS) and mental component summary (MCS) scores were 46 ± 10 and 47 ± 10, respectively. Controlling for confounding variables, low BMD at the femoral neck was associated with worse PCS scores (p = 0.010) and MCS scores (p = 0.034) in patients without fracture. In patients with a history of fracture, this relationship was less evident, and younger age (p < 0.00), increasing BMI (p = 0.016) and number of co-morbidities (p = 0.042) were associated with reductions in PCS scores.

Conclusions

Patients referred for BMD assessment before a diagnosis of osteoporosis had reduced PCS scores. In patients without fracture, low BMD contributed to this reduction in health-related quality of life. Low PCS scores in patients with fracture were seen only in younger subjects with osteoporosis.

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Acknowledgments

SW was funded by Charles Salt Trust funds. The authors would like to thank the bone densitometry team at The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry.

Conflict of interest

MWJD has received speaker fees from Amgen, Pfizer and Servier and has acted as a consultant to Servier.

Author information

Authors and Affiliations

  1. School of Sport Health and Exercise Sciences, Bangor University, George Building, Holyhead Road, Bangor, Gwynedd, LL57 2PZ, UK

    Sally Wilson

  2. Division of Clinical Chemistry, Department of Clinical and Experimental Medicine, Linköping University, 581 85, Linköping, Sweden

    Christopher A. Sharp

  3. Bone Health Service, Charles Salt Laboratories, Robert Jones & Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Shropshire, SY10 7AG, UK

    Michael W. J. Davie

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  1. Sally Wilson
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Correspondence to Sally Wilson.

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Wilson, S., Sharp, C.A. & Davie, M.W.J. Health-related quality of life in women referred for bone density assessment: relationships with bone mineral density, fracture and co-morbidity. Qual Life Res 24, 1235–1243 (2015). https://doi.org/10.1007/s11136-014-0851-0

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