Abstract
The Helping to End Addiction Long-Term (HEAL) Prevention Cooperative (HPC) is rapidly developing 10 distinct evidence-based interventions for implementation in a variety of settings to prevent opioid misuse and opioid use disorder. One HPC objective is to compare intervention impacts on opioid misuse initiation, escalation, severity, and disorder and identify whether any HPC interventions are more effective than others for types of individuals. It provides a rare opportunity to prospectively harmonize measures across distinct outcomes studies. This paper describes the needs, opportunities, strategies, and processes that were used to harmonize HPC data. They are illustrated with a strategy to measure opioid use that spans the spectrum of opioid use experiences (termed involvement) and is composed of common “anchor items” ranging from initiation to symptoms of opioid use disorder. The limitations and opportunities anticipated from this approach to data harmonization are reviewed. Lastly, implications for future research cooperatives and the broader HEAL data ecosystem are discussed.
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Notes
HPC data collection is ongoing and data analyses have not yet occurred.
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Funding
This research was supported by the National Institutes of Health through the NIH HEAL Initiative as part of the HEAL Prevention Initiative. The authors gratefully acknowledge the collaborative contributions of the National Institute on Drug Abuse (NIDA) and support from the following awards: Emory University and the Cherokee Nation (UH3DA050234; MPIs Kelli Komro, Terrence Kominsky, Juli Skinner); Massachusetts General Hospital (UH3DA050252; MPIs Timothy Wilens, Amy Yule); The Ohio State University (UH3DA050174; MPIs Natasha Slesnick, Kelly Kelleher); Oregon Social Learning Center (UH3DA050193, Lisa Saldana); RAND Corporation (UH3DA050235, Elizabeth D’Amico, Daniel Dickerson); RTI International (U24DA050182; MPIs Phillip Graham, Ty Ridenour); Seattle Children’s Hospital and University of Washington (UH3DA050189; MPIs Kym Ahrens, Kevin Haggerty); Texas Christian University (UH3DA050250; PI Danica Knight); University of Michigan (UH3DA050173; MPIs Maureen Walton, Erin Boner); University of Oregon (P50DA048756; Elizabeth Stormshak); and Yale University (UH3DA050251; PI Lynn Fiellin).
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Ridenour, T.A., Cruden, G., Yang, Y. et al. Methodological Strategies for Prospective Harmonization of Studies: Application to 10 Distinct Outcomes Studies of Preventive Interventions Targeting Opioid Misuse. Prev Sci 24 (Suppl 1), 16–29 (2023). https://doi.org/10.1007/s11121-022-01412-1
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DOI: https://doi.org/10.1007/s11121-022-01412-1