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Reducing substance use during adolescence: a translational framework for prevention

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Abstract

Rationale

Most substance use is initiated during adolescence when substantial development of relevant brain circuitry is still rapidly maturing. Developmental differences in reward processing, behavioral flexibility, and self-regulation lead to changes in resilience or vulnerability to drugs of abuse depending on exposure to risk factors. Intervention and prevention approaches to reducing addiction in teens may be able to capitalize on malleable brain systems in a predictable manner.

Objective

This review will highlight what is known about how factors that increase vulnerability to addiction, including developmental stage, exposure to early life adversity (ranging from abuse, neglect, and bullying), drug exposure, and genetic predisposition, impact the development of relevant systems.

Results and conclusions

Appropriate, early intervention may restore the normal course of an abnormal trajectory and reduce the likelihood of developing a substance use disorder (SUD) later in life. A considerable amount is known about the functional neuroanatomy and/or pharmacology of risky behaviors based on clinical and preclinical studies, but relatively little has been directly translated to reduce their impact on addiction in high-risk children or teenagers. An opportunity exists to effectively intervene before adolescence when substance use is likely to emerge.

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Acknowledgements

We gratefully acknowledgement grants by R01 DA15403, DA-026485, MH-091114 and the Simches family for their support.

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  1. Laboratory of Developmental Neuropharmacology, McLean Hospital and Department of Psychiatry, Harvard Medical School, Mailstop 333, 115 Mill Street, Belmont, MA, 02478, USA

    Jessica J. Stanis & Susan L. Andersen

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Stanis, J.J., Andersen, S.L. Reducing substance use during adolescence: a translational framework for prevention. Psychopharmacology 231, 1437–1453 (2014). https://doi.org/10.1007/s00213-013-3393-1

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