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A systematical review on ethnobotanical, phytochemical and pharmacological aspects of Dendrobium nobile Lindl.

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Abstract

Dendrobium nobile Lindl (DNL) is one of the main sources of traditional Chinese medicine, Shihu (Dendrobii caulis). In recent years, the strong antitumor activity of the extract from DNL makes it a hot research object. This paper systematically summarizes the researches of DNL from 1935 to 2022, including the botanical characteristics, herbal textual research, chemical composition, pharmacological activity and toxicology of DNL, in order to provide inspiration for the later research, further development, as well as reasonable application of DNL. The stems of DNL contains alkaloids, polysaccharides, sesquiterpenes, Phenanthrenes, benzenes and other chemical components. Among them, alkaloids and polysaccharides have been regarded as the main active constitutents, with dendrobine (1) the characteristic components. So far, as many as 213 compounds have been isolated from DNL, and 101 compounds have been identified from the flowers of DNL via gas chromatography-mass spectrometry (GC–MS). It has been found that the extract of DNL exhibit various pharmacological activities, such as anti-tumor, blood sugar reduction, nerve protection, immuneenhancement, anti-inflammation, and anti-aging. Most of the pharmacological researches are on the total polysaccharides and total alkaloids of DNL. Besides being used as a medicinal material, DNL also often appears in daily diet and health care. However, the toxicity of DNL was reported in some literatures. Therefore, more in-depth toxicological research is needed to ensure the safety of DNL in medicine and food consumption.

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Abbreviations

DNL:

Dendrobium nobile Lindl.

DNLA:

Dendrobium nobile Lindl. alkaloids

DNLP:

Dendrobium nobile Lindl. Polysaccharides

ED50 :

Median effective dose

IC50 :

50% Inhibiting concentration

DPPH:

1,1-Diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl

ORAC:

Oxygen radical absorbance capacity

VitC:

Vitamin C

BHT:

Butylated hydroxytoluene

FHCC-98:

Human hepatoma cell line

NO:

Nitric oxide

MIC:

Minimum inhibitory concentration

SGC-7901:

Human gastric cancer cells

K562:

Human chronic myeloid leukemia cells

A549:

Human non-small cell lung cancer cells

BEL-7402:

Human hepatocellular carcinoma cells

Hela:

Human cervical carcinoma cells

HepG2:

Human hepatocellular carcinoma cells

MCF-7:

Human breast cancer cells

SK-OV-3:

Human ovarian cancer cells

HL-60:

Human promyelocytic leukemia cells

PC12:

Rat pheochromocytoma cells

MG63:

Human osteosarcoma cells

U2OS:

Human osteosarcoma cells

MDA-MB-231:

Triple negative breast cancer cells

MDA-MB-453:

Triple negative breast cancer cells

TNF-a:

Tumor necrosis factor-α

IL-6:

Interleukin-6

IL-1β:

Interleukin-1β

COX-2:

Cyclooxygenase-2

HO-8910PM:

Human ovarian cancer cells

S-180:

Mouse sarcoma cells

MTT:

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

FCM:

Flow cytometry

GIP:

Glucose dependent insulin secreting peptide

6-OHDA:

6-Hydroxydopamine

LPS:

Lipopolysaccharide

Con A:

Knife-beetle protein A

iNOS:

Inducible nitric oxide synthase

ABTS:

2, 2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)

TGF-β1:

Transforming growth factor β1

α-SMA:

α-Smooth muscle actin

4NQO:

4-Nitroquinoline N-oxide

MNNG:

N-methyl-N'-nitro-N-nitrosoguanidine

AFB1:

Aflatoxin B1

UV:

Ultraviolet

CC:

Column chromatography

ODS:

Octadecylsilane silica

TLC:

Thin-layer chromatography

GC:

Gas chromatography

UPLC:

Ultra performance liquid chromatography

ESI:

Electrospray ionization

MS:

Mass spectrometry

HPLC:

High performance liquid chromatography

DAD:

Diode array detection

MSn:

Multi-stage tandem mass spectrometry

R&D:

Research and development

TCM:

Traditional Chinese medicine

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Acknowledgements

This work was supported by the “Student’s Platform for Innovation and Entrepreneurship Trainig Program” (S202110632258). Key Laboratory of Southwest Wildlife Resources Conservation, Ministry of Education (XNYB18-05). Yibin-Southwest Medical University joint Project (2019-YBXNYD-4).

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  1. Qian Zhang and Xiujuan Fu contributed equally to the work.

Authors and Affiliations

  1. School of Pharmacy, Southwest Medical University, Luzhou, 646000, People’s Republic of China

    Qian Zhang, Xiujuan Fu, Hao Liu, Yangxi Chen, Siwei Chen, Hong Niu, Yu Luo, Hui Lei & Dan Zhang

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Contributions

HL, DZ and QZ contributed to conception and design of the study. XF, YC and HL performed the literature collection. QZ, HN and YL performed data analysis. QZ, XF, SC and HL wrote the first draft of the manuscript. All authors contributed to manuscript revision, read, and approved the submitted version.

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Correspondence to Hui Lei or Dan Zhang.

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Zhang, Q., Fu, X., Liu, H. et al. A systematical review on ethnobotanical, phytochemical and pharmacological aspects of Dendrobium nobile Lindl.. Phytochem Rev 22, 743–780 (2023). https://doi.org/10.1007/s11101-023-09858-z

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