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Bioactive diterpenoids from Celastraceae species

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Abstract

Celastraceae species have a long tradition of use in folk medicine and agriculture. Intensive research into this family has resulted in the isolation of a large number of secondary metabolites with a wide range of bioactivity, with the most characteristic being the dihydro-β-agarofuran sesquiterpenes and the quinomethide triterpenoids. Despite diterpenoids not often being found in Celastraceae species, the novelty of their structures and their biological activities has stimulated their research. There are several reviews covering studies on Tripterigium wilfordii, a traditional Chinese medicine, and their metabolites, but none focusing on bioactive diterpenoids isolated from other Celastraceae species. This review focuses on diterpenes isolated from Celastraceae species, and their skeleton diversity, species sources, and tested biological activities are discussed. The literature from January 2000 to October 2016 is reviewed, and 64 references are cited. A total of 118 isolated diterpenoids possessing twelve different skeletons are included and classified by the following tested biological activity: cytotoxicity, anti-inflammatory, antitumour-promotion, anti-HIV, immunosuppressant, reversal multi-drug resistance, and antifeedant. This compliance information will be helpful in further research into diterpene Celastraceae isolation, biological activity determination and structure specific modifications.

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Acknowledgements

This study was supported by the Fundación CajaCanarias SALUCAN03 and SAF2015-65113-C2-1-R MINECO, Spain projects, and by FEDER funds from the EU.

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Authors and Affiliations

  1. Departamento de Química Orgánica, Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna and Instituto Canario de Investigación del Cáncer, Avenida Astrofísico Francisco Sánchez 2, 38206, La Laguna, Tenerife, Spain

    Isabel L. Bazzocchi, Marvin J. Núñez & Carolina P. Reyes

  2. Laboratorio de Investigación en Productos Naturales, Facultad de Química y Farmacia, Universidad de El Salvador, Final de Avenida Mártires y Héroes del 30 de Julio, San Salvador, El Salvador

    Marvin J. Núñez

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  1. Isabel L. Bazzocchi
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  2. Marvin J. Núñez
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Correspondence to Isabel L. Bazzocchi.

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Bazzocchi, I.L., Núñez, M.J. & Reyes, C.P. Bioactive diterpenoids from Celastraceae species. Phytochem Rev 16, 861–881 (2017). https://doi.org/10.1007/s11101-017-9494-4

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  • DOI: https://doi.org/10.1007/s11101-017-9494-4

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