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Parents’ perspectives towards paediatric confectionary masked medications: a qualitative study

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Abstract

Background The availability of age-appropriate, taste-masked oral solid medications for the paediatric population is currently inadequate. We have developed a novel chocolate-based drug delivery platform to taste-mask bitter drugs commonly utilised in the hospital setting, but there is limited evidence regarding parent’s perspectives on these medications. Aim To identify key themes regarding parents’ perspectives on taste-masked medications that look like confectionary. Additionally, to explore and identify the various barriers and facilitators to using oral medication among the paediatric population.Methods Qualitative descriptive study (July to August 2020) at a single tertiary paediatric hospital (Perth Children’s Hospital—PCH). Parents with at least one child (2–18 years) that underwent any elective operation at PCH were included in the study, in total 17 were interviewed. Results The two primary themes that underpinned parent’s perspectives on taste-masked medications that look like confectionary were medication safety and taste. Majority of parents supported the use of the proposed medication on the basis that the favourable taste profile will facilitate oral consumption, as opposed to their previous experiences with conventional paediatric medications that do not taste mask the bitter flavour. However, medication safety, in the forms of patient education and appropriate packaging, must be considered to minimise harmful misuse of the proposed medication. Conclusion Participants unanimously support the short-term use of taste-masked medications that look like confectionary, particularly in the hospital setting. However, patient education is highly sought after by parents regarding the role of these medications, to ensure medication safety with their children.

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References

  1. Venables R, Batchelor H, Hodson J, et al. Determination of formulation factors that affect oral medicines acceptability in a domiciliary paediatric population. Int J Pharm. 2015;480:55–62.

    Article  CAS  PubMed  Google Scholar 

  2. El-Rachidi S, Larochelle JM, Morgan JA. Pharmacists and pediatric medication adherence: bridging the gap. Hosp Pharm. 2017;52:124–31.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Bachmanov AA, Beauchamp GK. Taste receptor genes. Annu Rev Nutr. 2007;27(1):389–414.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Shi P, Zhang J, Yang H, et al. Adaptive diversification of bitter taste receptor genes in mammalian evolution. Mol Biol Evol. 2003;20(5):805–14.

    Article  CAS  PubMed  Google Scholar 

  5. Melis M, Errigo A, Crnjar R, et al. TAS2R38 bitter taste receptor and attainment of exceptional longevity. Sci Rep. 2019;9(1):1–9.

    Article  Google Scholar 

  6. Mennella JA, Roberts KM, Mathew PS, et al. Children’s perceptions about medicines: individual differences and taste. BMC Pediatr. 2015;15:130–5.

    Article  PubMed  PubMed Central  Google Scholar 

  7. European Parliament and the Council of the European Union Regulation (EC) n. 2006 of the European Parliament and of the Council of 20 December 2006 amending Regulation 1901⁄2006 on medicinal products for paediatric use. Off J Eur Union. 1902;1902(2006):20–1.

    Google Scholar 

  8. Tang EKY, Nguyen MN, Benington LR, et al. Storage stability of chocolate-based CDS formulations of midazolam and tramadol as whole tablets, quarter sized tablets and as reconstituted aqueous liquids. J Drug Deliv Sci Technol. 2021;64:102574.

    Article  CAS  Google Scholar 

  9. Yuen VM, Bailey CR. Premedication in children: does taste matter? Anaesthesia. 2018;73:1453–6.

    Article  CAS  PubMed  Google Scholar 

  10. Cheung LC, Nguyen M, Tang E, et al. Taste evaluation of a novel midazolam tablet for pediatric patients: in vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles. Int J Pharm. 2018;535:194–200.

    Article  CAS  PubMed  Google Scholar 

  11. Santer M, Ring N, Yardley L, et al. Treatment non-adherence in pediatric long-term medical conditions: systematic review and synthesis of qualitative studies of caregivers’ views. BMC Pediatr. 2014;14:63.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Gale NK, Heath G, Cameron E, et al. Using the framework method for the analysis of qualitative data in multi-disciplinary health research. BMC Med Res Methodol. 2013;13:117.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Vasileiou K, Barnett J, Thorpe S, et al. Characterising and justifying sample size sufficiency in interview-based studies: systematic analysis of qualitative health research over a 15-year period. BMC Med Res Methodol. 2018;18:148.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Bengtsson M. How to plan and perform a qualitative study using content analysis. NursingPlus Open. 2016;2:8–14.

    Article  Google Scholar 

  15. Machen S, Jani Y, Turner S, et al. The role of organizational and professional cultures in medication safety: a scoping review of the literature. Int J Qual Health Care. 2019;31:146–57.

    Article  Google Scholar 

  16. Easton KL, Chapman CB, Brien JA. Frequency and characteristics of hospital admissions associated with drug-related problems in paediatrics. Br J Clin Pharmacol. 2004;57(5):611–5.

    Article  PubMed  PubMed Central  Google Scholar 

  17. American Association of Poison Control Centres. Medication Safety for Children. Arch Pediatr Adolesc Med. 2010;164:208. https://doi.org/10.1001/archpediatrics.2009.281.

    Article  Google Scholar 

  18. Stebbing C, Wong IC, Kaushal R, et al. The role of communication in paediatric drug safety. Arch Dis Child. 2007;92:440–5.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Baghele A, Dave N, Dias R, et al. Effect of preoperative education on anxiety in children undergoing day-care surgery. Indian J Anaesth. 2019;63:565.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Nagae M, Nakane H, Honda S, et al. Factors affecting medication adherence in children receiving outpatient pharmacotherapy and parental adherence. J Child Adolesc Psychiatr Nurs. 2015;28:109–17.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Boyatzis RE. Transforming qualitative information: Thematic analysis and code development. Thousand Oaks, California: SAGE Publications; 1998.

    Google Scholar 

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Acknowledgements

The authors wish to thank the study participants and the anaesthesia department in Perth Children’s Hospital for their contribution to the research.

Funding

No funding was received for this study. BvUS is part funded by the Stan Perron Charitable Foundation. 

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Correspondence to Britta S. von Ungern-Sternberg.

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Jeon, A., Han, E., Lee, K. et al. Parents’ perspectives towards paediatric confectionary masked medications: a qualitative study. Int J Clin Pharm 44, 374–380 (2022). https://doi.org/10.1007/s11096-021-01349-5

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