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Acetaminophen and Thiosalicylic Acid Sensor Based on Carbon Paste Electrode Modified with Multi-Walled Carbon Nanotubes and Natural Deep Eutectic Solvent

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Pharmaceutical Chemistry Journal Aims and scope

A carbon paste electrode (CPE) modified with multi-walled carbon nanotubes (MWCNTs) and natural deep eutectic solvent (NADES) was prepared and applied for the simultaneous voltammetric determination of acetaminophen (ACP) and thiosalicylic acid (TSA) in real samples. Electrochemical impedance spectroscopy (EIS) was applied for investigation of electron transfer rate of [Fe(CN)6]3-/4- as a redox couple probe on the MWCNTs/NADES/CPE surface. The modified electrode preserved and combined the properties of individual modifiers synergistically. Significant enhancement in the peak current responses of ACP and TSA were observed at the modified electrode compared to the bare electrode. Under the optimal conditions, a linear dynamic range of 5–2900 μM for ACP and 5–2250 μM for TSA was obtained. The limit of detection (LOD) for ACP and TSA were 4.71 μM and 4.35 μM, respectively. Finally, this method was successfully employed for the determination of ACP and TSA in real samples.

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Authors and Affiliations

  1. Department of Basic Sciences, Farhangian University, Tehran, Iran

    Ebrahim Zarei

  2. Department of Chemistry, Semnan University, Semnan, Iran

    Maryam Vafadar & Alireza Asghari

Authors
  1. Ebrahim Zarei
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  2. Maryam Vafadar
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  3. Alireza Asghari
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Correspondence to Ebrahim Zarei.

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Zarei, E., Vafadar, M. & Asghari, A. Acetaminophen and Thiosalicylic Acid Sensor Based on Carbon Paste Electrode Modified with Multi-Walled Carbon Nanotubes and Natural Deep Eutectic Solvent. Pharm Chem J 57, 1862–1871 (2024). https://doi.org/10.1007/s11094-024-03090-5

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