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Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies

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Abstract

A new, repeatable, and rapid method has been developed for resolution of binary mixtures of acetaminophen and diclofenac with minimum sample pretreatment and without separation of the analytes. The method, based on the PLS1 processing of absorbance data in the UV region, was successfully used for quantification of the drug content of three tablet preparations. The results obtained were in good agreement with HPLC recovery data. The method also enabled determination of drug-dissolution profiles of these commercial tablets, by simultaneous determination of both analytes during the dissolution test.

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Acknowledgements

The authors thank SECyT-UNR and Fundación Antorchas for financial support. T.S.K. and R.M.M. are thankful to CONICET.

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Authors and Affiliations

  1. Area Análisis de Medicamentos, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario (S2002LRK), Argentina

    Patricia M. Castellano, Silvana E. Vignaduzzo, Rubén M. Maggio & Teodoro S. Kaufman

  2. Instituto de Química Orgánica de Síntesis -IQUIOS- (CONICET-UNR), Suipacha 531, Rosario (S2002LRK), Argentina

    Teodoro S. Kaufman

Authors
  1. Patricia M. Castellano
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  2. Silvana E. Vignaduzzo
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  3. Rubén M. Maggio
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  4. Teodoro S. Kaufman
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Corresponding author

Correspondence to Teodoro S. Kaufman.

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Castellano, P.M., Vignaduzzo, S.E., Maggio, R.M. et al. Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies. Anal Bioanal Chem 382, 1711–1714 (2005). https://doi.org/10.1007/s00216-005-3314-1

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  • DOI: https://doi.org/10.1007/s00216-005-3314-1

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