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Creation of Modified Forms of Amiodarone with Glycyrrhizic Acid and Its Monoammonium Salt and Study of Their Cytotoxicity on Hela Cells

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Pharmaceutical Chemistry Journal Aims and scope

The aim of this work is to create new modified dosage forms of amiodarone with triterpene glycosides in various stoichiometric ratios and to study their cytotoxicity on HeLa cells. Complexes of glycyrrhizic acid (GA) and the monoammonium salt of glycyrrhizic acid (MASGA) with amiodarone hydrochloride were obtained, characterized by certain physicochemical parameters, and studied by IR and UV spectroscopy. The supramolecular complexes were formed mainly through weak intermolecular interactions such as hydrogen bonding and ion-dipole, electrostatic, and dipole-dipole interactions. The quantitative content of GA and MASGA in the complexes was shown to affect the cytotoxicity of the drug. A modified form of amiodarone may be developed in future research and could become a promising antiarrhythmic drug.

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Authors and Affiliations

  1. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, 83 Mirzo Ulugbek St, 100125, Tashkent, Uzbekistan

    Kh. A. Yuldashev, R. S. Esanov, H. T. Saidullaeva, V. V. Uzbekov, M. K. Salakhutdinova, Z. S. Khashimova, M. B. Gafurov, Yu. I. Oshchepkova & Sh. I. Salikhov

Authors
  1. Kh. A. Yuldashev
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  2. R. S. Esanov
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  3. H. T. Saidullaeva
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  4. V. V. Uzbekov
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  5. M. K. Salakhutdinova
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  6. Z. S. Khashimova
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  7. M. B. Gafurov
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  8. Yu. I. Oshchepkova
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  9. Sh. I. Salikhov
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Correspondence to Yu. I. Oshchepkova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 12, pp. 38 – 44, December, 2023.

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Yuldashev, K.A., Esanov, R.S., Saidullaeva, H.T. et al. Creation of Modified Forms of Amiodarone with Glycyrrhizic Acid and Its Monoammonium Salt and Study of Their Cytotoxicity on Hela Cells. Pharm Chem J 57, 1726–1731 (2024). https://doi.org/10.1007/s11094-024-03072-7

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  • DOI: https://doi.org/10.1007/s11094-024-03072-7

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