Water-soluble 1H-indol-5-, 6-, 7-ylammonium chloroacetates were obtained from the reaction of substituted 1H-indol-5-, 6-, 7-ylamines with chloroacetic acid; identified based on PMR, UV, and mass spectra; and screened in the laboratory for antimicrobial activity. All the tested compounds could suppress the growth of microorganism test strains at various minimum inhibitory concentrations (MICs). The MIC values were observed to depend on the nature and pattern of substitution on the indole system.
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References
S. A. Yamashkin, I. S. Stepanenko, and N. V. Zhukova, Natural and Synthetic Biologically Active Compounds [in Russian], RITs MGPI, Saransk (2020).
I. S. Stepanenko, S. A. Yamashkin, Y. A. Kostina, et al., Bull. Russ. State Med. Univ., 2, 57 – 64 (2019).
I. S. Stepanenko, S. A. Yamashkin, A. I. Kot’kin, and M. A. Yurovskaya, Vestn. Mosk. Univ., Ser. 2: Khim, 60(5), 313 – 317 (2019); Moscow Univ. Chem. Bull., 74(5), 236 – 240 (2019).
I. S. Stepanenko, S. A. Yamashkin, and M. A. Yurovskaya, Vestn. Mosk. Univ., Ser. 2: Khim., 62(1), 37 – 43 (2021); Moscow Univ. Chem. Bull., 75(1), 382 – 388 (2020).
E. A. Alyamkina, N. V. Zhukova, G. A. Solodovnikova, and S. A. Yamashkin, Synthesis of Indole Systems [in Russian], Mordov. Gos. Ped. Inst., Saransk (2010).
MUK 4.2.1890 – 04. Methodical Instructions, Klin. Mikrobiol. Antimikrobn. Khimioter., 6, No. 4 (2004).
A. N. Mironov (ed.), Handbook for Preclinical Drug Studies [in Russian], Grif i K, Moscow (2012).
R. S. Kozlov,M. V. Sukhorukova, M. V. Eidel’shtein, et al., Determination of the Sensitivity of Microorganisms to Antimicrobial Drugs: Clinical Recommendations [in Russian], Smolensk (2018).
E. N. Padeiskaya, Infekts. Antimikrobn. Ter., 5, 150 – 155 (2001).
T. A. Lang and M. Secic, How to Report Statistics in Medicine, American College of Physicians, Philadelphia (2006).
S. A. Yamashkin, Doctoral Dissertation in Chemical Sciences, Moscow (1998).
R. A. Khmel’nitskii, Khim. Geterotsikl. Soedin., 3, 291 – 309 (1974).
P. B. Terent’ev and F. P. Stankyavichus, Mass Spectrometry of Biologically Active Nitrogenous Bases [in Russian], Mokslas, Vilnius (1987).
P. B. Terent’ev, Mass Spectrometry in Organic Chemistry [in Russian], Vysshaya Shkola, Moscow (1979).
A. T. Lebedev, Mass Spectrometry in Organic Chemistry [in Russian], TEKHNOSFERA, Moscow (2015).
E. S. Il’inykh, Mass Spectrometry in Organic Chemistry [in Russian], Izdatel’skii Tsentr YuUrGU, Chelyabinsk (2016).
E. S. Vasil’ev, Khim. Bezop., 3, 78 – 88 (2019).
A. A. Maseikina, I. S. Stepanenko, S. A. Yamashkin, and E. D. Slastnikov, Infekts. Immun., 11, No. 4, 663 – 670 (2021).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 10, pp. 16 – 21, October, 2023.
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Yamashkin, S.A., Stepanenko, I.S., Kiryutina, A.I. et al. Chloroacetates of Substituted 1H-Indol-5-,6-,7-Ylamines and Their Antimicrobial Activity. Pharm Chem J 57, 1546–1551 (2024). https://doi.org/10.1007/s11094-024-03047-8
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DOI: https://doi.org/10.1007/s11094-024-03047-8