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Evaluation of the Long-Term Action of Cinnarizine Nanoparticles Based on Poly(D,L-Lactide-Co-Glycolide)

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Pharmaceutical Chemistry Journal Aims and scope

The long-term pharmacological action of cinnarizine nanoparticles based on biodegradable poly(D,L-lactide-co-glycolide) (PLGA) was studied using adult male Wistar rats (240 – 260 g). The reference drug was cinnarizine substance at a dose of 5.6 mg/kg. Changes in the cerebral hemodynamics were studied by ultrasound dopplerography, measured as the level of cerebral blood flow recorded over time intervals of 2, 4, 6, 8, 10, and 12 h and characterized by indicators of systolic linear and volumetric velocities of cerebral hemodynamics in terms of the Pourcelot and Gosling indices. The study revealed prolongation of the cinnarizine effect for 12 h, which favorably distinguished the developed PLGA dosage form from other drugs available on the pharmaceutical market, which is likely to mitigate side effects of the parent drug.

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Authors and Affiliations

  1. Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University, Ministry of Health of the Russian Federation, 11 Kalinina Prosp., Pyatigorsk, 357532, Russia

    M. V. Sorokoumova, D. I. Pozdnyakov, D. V. Kompantsev, L. I. Shcherbakova, V. A. Kompantsev, N. S. Zyablitseva, K. A. Miroshnichenko & E. G. Sannikova

Authors
  1. M. V. Sorokoumova
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  2. D. I. Pozdnyakov
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  3. D. V. Kompantsev
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  4. L. I. Shcherbakova
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  5. V. A. Kompantsev
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  6. N. S. Zyablitseva
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  7. K. A. Miroshnichenko
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  8. E. G. Sannikova
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Corresponding author

Correspondence to M. V. Sorokoumova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 8, pp. 38 – 42, August, 2021.

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Sorokoumova, M.V., Pozdnyakov, D.I., Kompantsev, D.V. et al. Evaluation of the Long-Term Action of Cinnarizine Nanoparticles Based on Poly(D,L-Lactide-Co-Glycolide). Pharm Chem J 55, 706–710 (2021). https://doi.org/10.1007/s11094-021-02481-2

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  • DOI: https://doi.org/10.1007/s11094-021-02481-2

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