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Magnetic Ferrite Nanoparticles as a Possible Platform for Magnetic-Resonance Contrast Agents

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Pharmaceutical Chemistry Journal Aims and scope

Ultra-small ferrite nanoparticles containing bivalent metal atoms (Fe, Mn, Mg, and Co) were synthesized as platforms for magnetic-resonance contrast agents affecting mainly T1 or T2 in magnetic resonance imaging (MRI). The synthetic conditions for the proposed aqueous nanoparticle solutions, in particular, factors affecting their dispersion and concentration were examined. The research results for the relaxation properties of the obtained ferrite solutions and the contrast behavior in laboratory animals showed that they were promising as contrast agents for diagnostic MRI in T1-mode.

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References

  1. M. Khairinisa, Y. Takatsuru, I. Amano, et al., Invest. Radiol., 53, 110 – 118 (2018).

    Article  CAS  Google Scholar 

  2. A. G. Akopdzhanov, N. L. Shimanovskii, T. A. Fedotcheva, et al., Biofizika, 61(6), 1073 – 1078 (2016).

    Google Scholar 

  3. A. G. Akopdzhanov, N. L. Shimanovskii, V. Yu. Naumenko, et al., Vestn. RGMU, No. 2, 62 – 67 (2011).

  4. A. G. Akopdzhanov, N. L. Shimanovskii, I. P. Suzdalev, et al., Khim. Fiz., 33(7), 1 – 7 (2014).

    Google Scholar 

  5. A. G. Akopdzhanov, N. L. Shimanovskii, A. I. Borisova, et al., Biofizika, 63(3), 438 – 443 (2018).

    Google Scholar 

  6. N. L. Levshin and E. P. Krylova, Surface Effects in the Physics of Phase Transitions in Solids [in Russian], Fizicheskii Fakul’- tet MGU, Moscow (2008).

    Google Scholar 

  7. M. Zhang, Y. Cao, L. Wang, et al., ACS Appl. Mater. Interfaces, 7(8), 4650 – 4663 (2015).

    Article  CAS  Google Scholar 

  8. A. Lazarczyk, P. Halubiec, O. Szafranski, et al., Materials, 12(4), 617 – 643 (2019).

    Article  Google Scholar 

  9. C. Dispenza, N. Grimaldi, M. A. Sabatino, et al., J. Nanosci. Nanotechnol., 15, 3445 – 3467 (2015).

    Article  CAS  Google Scholar 

  10. Instructions (Information for Specialists) for Medical Use of Resovist Preparation [in Russian], manufactured by Schering AG Germany, D-13342 Berlin, Mullerstrasse, 178 (2003).

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Acknowledgments

The work was financially supported by the Russian Foundation for Basic Research (Grant No. 17-03-00539).

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Authors and Affiliations

  1. N. I. Pirogov Russian National Research Medical University, 1 Ostrovityanova St, Moscow, 117997, Russia

    A. G. Akopdzhanov, N. L. Shimanovskii, A. I. Borisova & V. A. Parshin

  2. National University of Science and Technology MISiS (Moscow Institute of Steel and Alloys), 4 Leninskii Prosp, Moscow, 119049, Russia

    G. A. Frolov

Authors
  1. A. G. Akopdzhanov
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  2. N. L. Shimanovskii
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  3. A. I. Borisova
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  4. V. A. Parshin
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  5. G. A. Frolov
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Corresponding author

Correspondence to A. G. Akopdzhanov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 12, pp. 38 – 41, December, 2019.

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Akopdzhanov, A.G., Shimanovskii, N.L., Borisova, A.I. et al. Magnetic Ferrite Nanoparticles as a Possible Platform for Magnetic-Resonance Contrast Agents. Pharm Chem J 53, 1164–1167 (2020). https://doi.org/10.1007/s11094-020-02141-x

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  • DOI: https://doi.org/10.1007/s11094-020-02141-x

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