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Development of a Parenteral Medicinal Formulation of the New Antifungal Semisynthetic Polyene Antibiotic Amphamide

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

The search for new antifungal agents with improved chemotherapeutic properties has produced the semisynthetic polyene macrolide amphotericin B derivative amphamide, which has a number of clear advantages over the starting antibiotic. The development of a medicinal formulation of amphamide for parenteral use is described, with high water solubility, good stability of the active ingredient, and high specific activity. The prototype composition has potential for a further full-scale set of clinical trials.

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Authors and Affiliations

  1. G. F. Gauze Science Research Institute for the Search for New Antibiotics, 119021, Moscow, Russia

    A. N. Tevyashova, E. N. Bychkova, S. E. Solov’eva, N. É. Grammatikova & A. E. Shchekotikhin

  2. D. I. Mendeleev Russian Chemical-Technological University, 125047, Moscow, Russia

    A. N. Tevyashova & A. E. Shchekotikhin

Authors
  1. A. N. Tevyashova
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  2. E. N. Bychkova
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  3. S. E. Solov’eva
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  4. N. É. Grammatikova
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  5. A. E. Shchekotikhin
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Corresponding author

Correspondence to A. N. Tevyashova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 10, pp. 50 – 53, October, 2019.

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Tevyashova, A.N., Bychkova, E.N., Solov’eva, S.E. et al. Development of a Parenteral Medicinal Formulation of the New Antifungal Semisynthetic Polyene Antibiotic Amphamide. Pharm Chem J 53, 976–980 (2020). https://doi.org/10.1007/s11094-020-02108-y

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  • DOI: https://doi.org/10.1007/s11094-020-02108-y

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