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Near-Infrared Spectroscopy for the Analysis of Solid Dosage Forms: Does the Shell Influence Drug Identification Results?

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Pharmaceutical Chemistry Journal Aims and scope

Several practical issues related to the need for sample preparation of solid dosage forms for their identification by near-infrared (NIR) spectroscopy are discussed. It is shown using a classification method, i.e., discriminant analysis, that the tablet coating regardless of its thickness did not affect the accuracy of the analytical results. However, calibration error due to the influence of opaque hard gelatin shells is possible during identification using diffuse reflectance spectra. It is proven that errors in assigning a sample to one group or another are avoided and; therefore, it is rapidly identified if the hard gelatin shell is removed and NIR spectra are recorded directly from the capsule contents.

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Authors and Affiliations

  1. Department of Pharmaceutical and Toxicological Chemistry, Peoples’ Friendship University of Russia, 8 – 2 Miklukho-Maklaya St., Moscow, 117198, Russia

    A. G. Gurzhieva & M. A. Morozova

  2. Farmanaliz Company, 2 Chermyanskaya St., Moscow, 127282, Russia

    T. E. Elizarova

Authors
  1. A. G. Gurzhieva
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  2. T. E. Elizarova
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  3. M. A. Morozova
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Corresponding author

Correspondence to A. G. Gurzhieva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 2, pp. 46 – 50, February, 2016.

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Gurzhieva, A.G., Elizarova, T.E. & Morozova, M.A. Near-Infrared Spectroscopy for the Analysis of Solid Dosage Forms: Does the Shell Influence Drug Identification Results?. Pharm Chem J 50, 114–119 (2016). https://doi.org/10.1007/s11094-016-1407-0

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  • DOI: https://doi.org/10.1007/s11094-016-1407-0

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