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Design of New Uracil Derivatives Possessing Inhibitory Activity with Respect to Reverse Transcriptase of HIV-1 Mutant K103N/Y181C

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Pharmaceutical Chemistry Journal Aims and scope

New highly active N 1-substituted uracil derivatives of the HIV-1 nonnucleoside reverse transcriptase inhibitor class were designed. The structure—activity relationship provided a basis for building a computer model of the inhibitory activity against reverse transcriptase of HIV-1 mutant K103N/Y181C. New compounds that were more active than nevirapine were synthesized.

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Authors and Affiliations

  1. Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University, MH RF, Pyatigorsk, 357532, Russia

    S. V. Pechinskii & A. G. Kuregyan

  2. Volgograd State Medical University, MH RF, Volgograd, 400131, Russia

    A. A. Ozerov & M. S. Novikov

Authors
  1. S. V. Pechinskii
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  2. A. G. Kuregyan
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  3. A. A. Ozerov
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  4. M. S. Novikov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 10, pp. 40 – 43, October, 2015.

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Pechinskii, S.V., Kuregyan, A.G., Ozerov, A.A. et al. Design of New Uracil Derivatives Possessing Inhibitory Activity with Respect to Reverse Transcriptase of HIV-1 Mutant K103N/Y181C. Pharm Chem J 49, 683–686 (2016). https://doi.org/10.1007/s11094-016-1353-x

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  • DOI: https://doi.org/10.1007/s11094-016-1353-x

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