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MicroRNAs and Child Neuropsychiatric Disorders: A Brief Review

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Abstract

MicroRNAs (miRNAs) are short, endogenous, noncoding RNAs that regulate gene expression through posttranscriptional mechanisms via degradation or inhibition of specific mRNAs targets. In recent years, abundant studies have illustrated the relevance of miRNAs in human psychopathology. In this current review, neuropsychiatric disorders with moderate to high prevalence among children and adolescents such as Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder, Dyslexia, Epilepsy, Schizophrenia and Tourette Syndrome were discussed focusing on the functional consequence of altered miRNA expression during the development of such diseases. The insight about the roles that miRNAs play in central nervous systems development such as cell proliferation and differentiation, synaptogenesis, synaptic plasticity, and apoptosis might be the key to explicate novel biomarkers for diagnosis and prognosis of these disorders, as well as the finding of new targets for drug development for therapeutic approaches.

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Author notes

  1. Paula Roxana Reyes and Betsabé Sánchez Garza have equally contributed to this work.

Authors and Affiliations

  1. Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, CP 76130, Querétaro, Mexico

    Sujay Paul, Paula Roxana Reyes, Betsabé Sánchez Garza & Ashutosh Sharma

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  1. Sujay Paul
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  2. Paula Roxana Reyes
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Paul, S., Reyes, P.R., Garza, B.S. et al. MicroRNAs and Child Neuropsychiatric Disorders: A Brief Review. Neurochem Res 45, 232–240 (2020). https://doi.org/10.1007/s11064-019-02917-y

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