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The Unwanted Cell Migration in the Brain: Glioma Metastasis

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Abstract

Cell migration is identified as a highly orchestrated process. It is a fundamental and essential phenomenon underlying tissue morphogenesis, wound healing, and immune response. Under dysregulation, it contributes to cancer metastasis. Brain is considered to be the most complex organ in human body containing many types of neural cells with astrocytes playing crucial roles in monitoring both physiological and pathological functions. Astrocytoma originates from astrocytes and its most malignant type is glioblastoma multiforme (WHO Grade IV astrocytoma), which is capable to infiltrate widely into the neighboring brain tissues making a complete resection of tumors impossible. Very recently, we have reviewed the mechanisms for astrocytes in migration. Given the fact that astrocytoma shares many histological features with astrocytes, we therefore attempt to review the mechanisms for glioma cells in migration and compare them to normal astrocytes, hoping to obtain a better insight into the dysregulation of migratory mechanisms contributing to their metastasis in the brain.

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Acknowledgements

This work was supported by the Beijing Natural Science Foundation (7091004); the National Basic Research Program of China (973 program) (2011CB504400); the National Natural Science Foundation of China (30870818, 31070974, 31171009 and 81471253 and 81671218); and the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (81221002).

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    1. Laboratory for Functional Study of Astrocytes, Neuroscience Research Institute, Peking University, 38 Xue Yuan Road, Beijing, 100191, China

      Xue Tao Qi, Jiang Shan Zhan, Li Ming Xiao, Lina Li, Han Xiao Xu, Zi Bing Fu, Yan Hao Zhang, Xi Hua Jia, Guo Ge, Rui Chao Chai, Kai Gao & Albert Cheung Hoi Yu

    2. Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China

      Xue Tao Qi, Jiang Shan Zhan, Li Ming Xiao, Lina Li, Han Xiao Xu, Zi Bing Fu, Yan Hao Zhang, Xi Hua Jia, Guo Ge, Rui Chao Chai, Kai Gao & Albert Cheung Hoi Yu

    3. Key Laboratory for Neuroscience, Ministry of Education, Peking University Health Science Center, Beijing, 100191, China

      Xue Tao Qi, Jiang Shan Zhan, Li Ming Xiao, Lina Li, Han Xiao Xu, Zi Bing Fu, Yan Hao Zhang, Xi Hua Jia, Guo Ge, Rui Chao Chai, Kai Gao & Albert Cheung Hoi Yu

    4. National Health and Family Planning Commission, Peking University Health Science Center, Beijing, 100191, China

      Xue Tao Qi, Jiang Shan Zhan, Li Ming Xiao, Lina Li, Han Xiao Xu, Zi Bing Fu, Yan Hao Zhang, Xi Hua Jia, Guo Ge, Rui Chao Chai, Kai Gao & Albert Cheung Hoi Yu

    5. Hai Kang Life (Beijing) Corporation Ltd., Sino-I Campus No.1, Beijing Economic-Technological Development Area, Beijing, 100176, China

      Lina Li, Xi Hua Jia, Rui Chao Chai & Albert Cheung Hoi Yu

    6. Hai Kang Life Corporation Ltd., Hong Kong Science Park, Shatin, New Territories, Hong Kong, China

      Lina Li, Xi Hua Jia, Rui Chao Chai & Albert Cheung Hoi Yu

    7. Department of Human Anatomy, Guizhou Medical University, Guian New Area, Guiyang, Guizhou, 550025, China

      Han Xiao Xu & Guo Ge

    8. Department of Pathology, Peking University Health Science Center and Peking University Third Hospital, Beijing, 100191, China

      Jing Zhang

    9. Department of Pathology, University of Washington School of Medicine, Seattle, WA, 98104, USA

      Jing Zhang

    10. Department of Pediatrics, Peking University First Hospital, Beijing, 100034, China

      Kai Gao

    11. Laboratory of Translational Medicine, Institute of Systems Biomedicine, Peking University, Beijing, 100191, China

      Albert Cheung Hoi Yu

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    1. Xue Tao Qi
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    Correspondence to Lina Li or Albert Cheung Hoi Yu.

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    Xue Tao Qi, Jiang Shan Zhan, and Li Ming Xiao have contributed equally to this manuscript.

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    Qi, X.T., Zhan, J.S., Xiao, L.M. et al. The Unwanted Cell Migration in the Brain: Glioma Metastasis. Neurochem Res 42, 1847–1863 (2017). https://doi.org/10.1007/s11064-017-2272-2

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    • DOI: https://doi.org/10.1007/s11064-017-2272-2

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