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Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats

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Abstract

The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)—a traditional medicine used for the seizure treatment in eastern country—may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls. Immunohistochemical analysis indicates that NS reduced astrogliosis in caudate and accumbens nuclei. These results suggest that NS may consider as an adjunct to antipsychotics to reduce the EPS-like side effect.

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Abbreviations

NS:

Nigella sativa

HAL + NS:

Haloperidol + Nigella sativa oil

VCMs:

Vacuous chewing movements

EPS:

Extrapyramidal symptoms

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Authors and Affiliations

  1. Neurochemistry and Biochemical Neuropharmacology Unit, Department of Biochemistry, The University of Karachi, Karachi, 75270, Pakistan

    Tafheem Malik & Darakhshan Jabeen Haleem

  2. Basic Sciences, Physiology, National University of Health Sciences, Lombard, IL, USA

    Tafheem Malik

  3. Histopathology Unit, Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan

    Tafheem Malik, Sheema Hasan & Shahid Pervez

  4. Department of Anatomy, United Medical and Dental College, Karachi, Pakistan

    Tasneem Fatima

  5. Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine and Drug Research, The University of Karachi, Karachi, Pakistan

    Darakhshan Jabeen Haleem

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  1. Tafheem Malik
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Correspondence to Tafheem Malik.

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Malik, T., Hasan, S., Pervez, S. et al. Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats. Neurochem Res 41, 3386–3398 (2016). https://doi.org/10.1007/s11064-016-2073-z

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  • DOI: https://doi.org/10.1007/s11064-016-2073-z

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