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Correlations between the Amount of Oxidatively Modified Proteins and Proteolytic Activity in the Rat Basal Nuclei after Acute Hypoxia

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Neurophysiology Aims and scope

We studied correlations between the intensity of accumulation of oxidatively modified proteins and the state of the system of proteolysis in the basal nuclei (nucl. caudatus, pallidum, nucl. accumbens of the septum, and amygdala) of the rat brain after an episode of intense acute hypobaric hypoxia. We demonstrated that, the processes of protein peroxidation in the basal ganglia are intensified under the action of hypoxia in a parallel manner with increase in proteolytic activity. Accumulation of oxidized proteins is considered a factor influencing the activity of proteolysis.

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  1. Bukovina State Medical University, Chernovtsy, Ukraine

    I. Yu. Sopova

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  1. I. Yu. Sopova
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Correspondence to I. Yu. Sopova.

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Sopova, I.Y. Correlations between the Amount of Oxidatively Modified Proteins and Proteolytic Activity in the Rat Basal Nuclei after Acute Hypoxia. Neurophysiology 46, 373–375 (2014). https://doi.org/10.1007/s11062-014-9457-y

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  • DOI: https://doi.org/10.1007/s11062-014-9457-y

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