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Clinical and prognostic features of spinal meningioma: a thorough analysis from a single neurosurgical center

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to thoroughly analyze the clinical characteristics of a large cohort of spinal meningioma (SM) from a single neurological center and identify risk factors associated with worse progression free survival and neurological function outcome.

Methods

Clinical information was retrieved from 483 SM and 9806 cranial meningioma cases who were operated in our center between 2003 and 2013. 194 SM patients who were followed at the main branch were used for prognostic analyses that included both recurrence free survival and neurological functions based on Modified McCormick scale (MMS).

Results

Females were predominant (P < 0.001). High grade tumors were not common (WHO grade II, 2.9%; grade III, 1.7%), while the clear cell subtype was frequent within grade II SMs (6/14, 42.9%). Macroscopic total resection was achieved in all SMs (Simpson grade I, 30.9%; grade II, 65.5%; grade III, 3.6%) with a low complications rate (4.6%) and provided neurological improvement in 80 patients (41.2%). Recurrence was seen in 9 cases (4.6%) and associated with high WHO grade, male, prior recurrence, and Simpson grade III. High WHO grade and high Ki-67 index were identified to be independent factors predictive of both neurological function deterioration and impaired post-operative neurological status.

Conclusions

Our analysis of the largest SM cohort in scale from a single institution offers a comprehensive view of the clinical characteristics of surgically treated SM, revealing the distinct biology of SM in comparison to its cranial counterparts, and providing guidance to improve surgical management of SM.

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Abbreviations

SM:

Spinal meningioma

MMS:

Modified McCormick scale

T1WI:

T1 Weighted image

MRI:

Magnetic resonance imaging

PR:

Progesterone receptor

PFS:

Progression free survival

SEP:

Somatosensory evoked potentials

MEP:

Motor evoked potentials

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Funding

The work has not been submitted elsewhere for publication, in whole or in part. This study was supported by grants from the National Natural Science Foundation of China (81772674 to Y. Gong) and the Science and Technology Commission of Shanghai Municipality (18140900200 and 16140903000 to Y. Gong).

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Author notes

  1. Lingyang Hua and Hongda Zhu have contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, 12# Middle Wulumuqi Road, Jingan District, Shanghai, 200040, China

    Lingyang Hua, Hongda Zhu, Jiaojiao Deng, Hailiang Tang, Shihai Luan, Qing Xie & Ye Gong

  2. Department of Critical Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

    Mi Tian, Xuewei Jiang & Ye Gong

  3. Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Hiroaki Wakimoto

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  1. Lingyang Hua
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  2. Hongda Zhu
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  9. Qing Xie
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  10. Ye Gong
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Corresponding authors

Correspondence to Qing Xie or Ye Gong.

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The authors had no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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Hua, L., Zhu, H., Deng, J. et al. Clinical and prognostic features of spinal meningioma: a thorough analysis from a single neurosurgical center. J Neurooncol 140, 639–647 (2018). https://doi.org/10.1007/s11060-018-2993-3

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  • DOI: https://doi.org/10.1007/s11060-018-2993-3

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