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Cognitive improvement in meningioma patients after surgery: clinical relevance of computerized testing

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Abstract

Cognitive dysfunction is common in patients with primary brain tumors, and may have a major impact on activities of daily living and on quality of life. This is the first prospective study that investigated the incidence and severity of cognitive dysfunction in meningioma patients before and after surgery, and the change in dysfunction over time, both at group and individual patient level. Sixty-eight meningioma patients were neuropsychologically tested one day before brain surgery. Sixty-two patients were followed up 3 months after surgery. All patients were assessed with a brief (30 min) computerized screening battery of neuropsychological tests (i.e., CNS Vital Signs). Pre- and post-operatively, meningioma patients demonstrated significantly lower scores in all cognitive domains; memory, psychomotor speed, reaction time, complex attention, cognitive flexibility, processing speed, and executive functioning, in comparison with normative data. Pre-operatively, 47 out of 68 patients (69 %) scored low or very low in one or more cognitive domains. Post-operatively, 27 out of 62 patients (44 %) scored within this range. Test performance improved in all cognitive domains post-operatively, with the exception of psychomotor speed and reaction time. In line with previous studies with conventional neuropsychological tests, meningioma patients are faced with cognitive dysfunction in several cognitive domains both pre- and post-operatively. However, a large proportion of patients shows post-operative improvement in cognitive functioning. Longer-term follow-up is recommended to identify potential predictors of cognitive improvement after surgery. Diagnosis and treatment of these cognitive deficits will improve outcomes and quality of life in meningioma patients.

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References

  1. Taphoorn MJB, Klein M (2004) Cognitive deficits in adult patients with brain tumors. Lancet Neurol 3(3):159–168

    Article  PubMed  Google Scholar 

  2. Shen C et al (2012) Cognitive deficits in patients with brain tumor. Chin Med J 125(14):2610–2617

    PubMed  Google Scholar 

  3. Tucha O et al (2003) Preoperative and postoperative cognitive functioning in patients with frontal meningiomas. J Neurosurg 98(1):21–31

    Article  PubMed  Google Scholar 

  4. Dijkstra M et al (2009) Late neurocognitive sequelae in patients with WHO grade I meningioma. J Neurol Neurosurg Psychiatry 80(8):910–915

    Article  CAS  PubMed  Google Scholar 

  5. van Nieuwenhuizen D et al (2013) Neurocognitive functioning and health-related quality of life in patients with radiologically suspected meningiomas. J Neurooncol 113(3):433–440

  6. Yoshii Y et al (2008) Cognitive function of patients with brain tumor in pre- and postoperative stage. Surg Neurol 69(1):51–61

    Article  PubMed  Google Scholar 

  7. van Nieuwenhuizen D et al (2007) Differential effect of surgery and radiotherapy on neurocognitive functioning and health-related quality of life in WHO grade I meningioma patients. J Neurooncol 84(3):271–278

  8. Krupp W et al (2009) Assessment of neuropsychological parameters and quality of life to evaluate outcome in patients with surgically treated supratentorial meningiomas. Neurosurgery 64(1):40–47

    Article  PubMed  Google Scholar 

  9. Tucha O, Smely C, Lange KW (2001) Effects of surgery on cognitive functioning of elderly patients with intracranial meningioma. Br J Neurosurg 15(2):184–188

    Article  CAS  PubMed  Google Scholar 

  10. Gualtieri CT, Johnson LG (2006) Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs. Arch Clin Neuropsychol 21(7):623–643

    Article  PubMed  Google Scholar 

  11. Snaith RP, Zigmond AS (1986) The hospital anxiety and depression scale. Br med j (Clin res ed.) 292(6516):344

    Article  CAS  Google Scholar 

  12. Snaith RP (1987) The concepts of mild depression. Br J Psychiatry: J Ment Sci 150:387–393

    Article  CAS  Google Scholar 

  13. Spinhoven P et al (1997) A validation study of the Hospital Anxiety and Depression Scale (HADS) in different groups of Dutch subjects. Psychol Med 27(2):363–370

    Article  CAS  PubMed  Google Scholar 

  14. Meskal I et al (2014) Cognitive deficits in patients with trigeminal neuralgia: opportunities to improve care and quality of life. Acta Neurochir 156(8):1565–1566

    Article  PubMed  Google Scholar 

  15. Wahlstorm M, Boersma FJ (1968) The influence of test-wiseness upon achievement. Educ Psychol Meas 28:413–420

    Article  Google Scholar 

  16. Bouma AMJ, Lindeboom J, Schmand B (2012) Handboek neuropsychologische diagnostiek, vol 2. Pearson, Amsterdam

  17. Iverson GL et al (2009) Does familiarity with computers affect computerized neuropsychological test performance? J Clin Exp Neuropsychol 31(5):594–604

    Article  PubMed  Google Scholar 

  18. Gehring K et al (2009) Cognitive rehabilitation in patients with gliomas: a randomized, controlled trial. J Clin Oncol 27(22):3712–3722

    Article  PubMed  Google Scholar 

  19. Verhage F Intelligentie en leeftijd Onderzoek bij Nederlanders van twaalf tot zevenenzeventig jaar. [Intelligence and age: Research study in Dutch individuals age twelve to seventy-seven]. 1964: Assen: Van Gorcum/Prakke & Prakke

  20. Cohen J (1992) A power primer. Psychol Bull 112(1):155–159

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We would like to thank all of the nurses and clinical assistants of the department of Neurosurgery.

Conflict of interest

None of the authors have any conflict of interests to declare.

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Authors and Affiliations

  1. Department of Cognitive Neuropsychology, Tilburg University, Warandelaan 2, PO Box 90153, 5000 LE, Tilburg, The Netherlands

    Ikram Meskal, Karin Gehring, Sophie D. van der Linden & Margriet M. Sitskoorn

  2. Department of Neurosurgery, St Elisabeth Hospital, Tilburg, The Netherlands

    Geert-Jan M. Rutten

Authors
  1. Ikram Meskal
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  2. Karin Gehring
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  3. Sophie D. van der Linden
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  4. Geert-Jan M. Rutten
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  5. Margriet M. Sitskoorn
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Correspondence to Karin Gehring.

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Meskal, I., Gehring, K., van der Linden, S.D. et al. Cognitive improvement in meningioma patients after surgery: clinical relevance of computerized testing. J Neurooncol 121, 617–625 (2015). https://doi.org/10.1007/s11060-014-1679-8

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  • DOI: https://doi.org/10.1007/s11060-014-1679-8

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