Parkinson’s disease (PD) is a slowly progressive neurodegenerative disease in which the main symptoms are movement disorders (bradykinesia, rigidity, resting tremor, and postural instability). However, continuing research into the disease identifies ever more new (non-motor) symptoms. This article discusses visual impairments occurring in PD patients, the pathogenetic mechanisms underlying them, and methods for their correction.
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References
Borm, C. D. J. M., Werkmann, M., Graaf, D., et al., “Undetected ophthalmological disorders in Parkinson’s disease,” J. Neurol., 269, No. 7, 1–12 (2022), https://doi.org/10.1007/s00415-022-11014-0.
Somov, E. E. and Obodov, V. A., Lacrimal Dysfunction Syndromes, Chelovek, St. Petersburg (2011).
Edman, M. C., Janga, S. R., Kakan, S. S., et al., “Tears – more to them than meets the eye: why tears are a good source of biomarkers in Parkinson’s disease,” Biomark. Med., 14, No. 2, 151–163 (2020), https://doi.org/10.2217/bmm-2019-0364.
Chen, Z., Li, G., and Liu, J., “Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment,” Neurobiol. Dis., 134, 104700 (2019), https://doi.org/10.1016/j.nbd.2019.104700.
Ulusoy, E. K. and Ulusoy, D. M., “Evaluation of corneal sublayers thickness and corneal parameters in patients with Parkinson’s disease,” Int. J. Neurosci., 131, No. 10, 939–945 (2021), https://doi.org/10.1080/00207454.2020.1761353.
Roda, M., Ciavarella, C., Giannaccare, G., and Versura, P., “Biomarkers in tears and ocular surface: a window for neurodegenerative diseases,” Eye Contact Lens, 46, S129–S134 (2020), https://doi.org/10.1097/ICL.0000000000000663.
Ekker, M. S., Janssen, S., Seppi, K., et al., “Ocular and visual disorders in Parkinson’s disease: common but frequently overlooked,” Parkinsonism Relat. Disord., 40, 1–10 (2017), https://doi.org/10.1016/j.parkreldis.2017.02.014.
Wang, M. T. M., Tien, L., Han, A., et al., “Impact of blinking on ocular surface and tear film parameters,” Ocul. Surf., 16, No. 4, 424–429 (2020), https://doi.org/10.1016/j.jtos.2018.06.001.
Avetisova, S. E., Egorova, E. A., and Moshetova, L. K., et al., Ophthalmology. National Guidelines, FEOTAR-Media, Moscow (2019), 2nd ed.
Brzhevskii, V. V., Diagnosis and Treatment of Dry Eye Syndrome, St. Petersburg State Pediatric Medical Academy (1998).
Savitt, J. and Aouchiche, R., “Management of visual dysfunction in patients with Parkinson’s disease,” J. Parkinsons Dis., 10, s1, S49–S56 (2020), https://doi.org/10.3233/JPD-202103.
Savitt, J. and Mathews, M., “Treatment of visual disorders in Parkinson disease,” Curr. Treat. Options Neurol., 20, No. 8, 30 (2018), https://doi.org/10.1007/s11940-018-0519-0.
Rouen, P. A. and White, M. L., “Dry eye disease: prevalence, assessment, and management,” Home Healthc. Now, 36, No. 2, 74–83 (2018), https://doi.org/10.1097/NHH.0000000000000652.
Borm, C. D. J. M., Smilowska, K., de Vries, N. M., et al., “The neuro-ophthalmological assessment in Parkinson’s disease,” J. Parkinsons Dis., 9, No. 2, 427–435 (2019), https://doi.org/10.3233/JPD-181523.
Levin, O. S. and Fedorova, N. V., Parkinson’s Disease, MEDpressinform, Moscow (2015), 5th ed.
Veys, L., Vandenabeele, M., Ortuno-Lizaran, I., et al., “Retinal alpha-synuclein deposits in Parkinson’s disease patients and animal models,” Acta Neuropathol., 137, No. 3, 379–395 (2019), https://doi.org/10.1007/s00401-018-01956-z.
Ortuno-Lizaran, I., Beach, T. G., Serrano, G. E., et al., “Phosphorylated α-synuclein in the retina is a biomarker of Parkinson’s disease pathology severity,” Mov. Disord., 33, No. 8, 1315–1324 (2018), https://doi.org/10.1002/mds.27392.
Bodis-Wollner, I., Kozlowsi, P. B., Glazman, S., and Miri, S., “α-synuclein in the inner retina in Parkinson disease,” Ann. Neurol., 75, No. 6, 964–966 (2014), https://doi.org/10.1002/ana.24182.
Beach, T. G., Carew, J., Serrano, G., et al., “Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson’s disease subjects,” Neurosci. Lett., 571, 34–38 (2014), https://doi.org/10.1016/j.neulet.2014.04.027.
Schapansky, J., Nardozzi, J. D., and LaVoie, M. J., “The complex relationships between microglia, α-synuclein and LRRK2 in Parkinson’s disease,” Neuroscience, 302, 74–88 (2015), https://doi.org/10.1016/j.neuroscience.2014.09.049.
Scheiblich, H., Dansokho, C., Mercan, D., et al., “Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes,” Cell, 184, No. 20, 5089–5106.e21 (2021), https://doi.org/10.1016/j.cell.2021.09.007.
Ramirez, A. I., de Hoz, R., Salobrar-Gracia, E., et al., “The role of microglia in retinal neurodegeneration: Alzgeimer’s disease, Parkinson, and glaucoma,” Front. Aging Neurosci., 9, 214 (2017), https://doi.org/10.3389/fnagi.2017.00214.
Miri, S., Glazman, S., Mylin, L., and Bodis-Wollner, I., “A combination of retinal morphology and visual electrophysiology testing increases diagnostic yield in Parkinson’s disease,” Parkinsonism Relat. Disord., 22, S134–S137 (2016), https://doi.org/10.1016/j.parkreldis.2015.09.015.
Perez-Fernandez, V., Milosavljevic, N., Allen, A. E., et al., “Rod photoreceptor activation alone defines the release of dopamine in the retina,” Curr. Biol., 29, No. 5, 763–774.e5 (2019), https://doi.org/10.1016/j.cub.2019.01.042.
Jackson, C. R., Ruan, G. X., Aseem, F., et al., “Retinal dopamine mediates multiple dimensions of light-adapted vision,” J. Neurosci., 32, No. 27, 9359–9368 (2012), https://doi.org/10.1523/JNEUROSCI.0711-12.2012.
Marrocco, E., Esposito, F., Tarallo, V., et al., “α-synuclein in the retina leads to degeneration of dopamine amacrine cells impairing vision,” BioRxiv, 760603 (2019), https://doi.org/10.1101/760603.
La Morgia, C., Ross-Cisneros, F. N., Sadun, A. A., and Carelli, V., “Retinal ganglion cells and circadian rhythms in Alzheimer’s disease, Parkinson’s disease and beyond,” Front. Neurol., 8, 162 (2017), https://doi.org/10.3389/fneur.2017.00162.
Vuong, H. E., Hardi, C. N., Barnes, S., and Brecha, N. C., “Parallel inhibition of dopamine amacrine cells and intrinsically photosensitive retinal ganglion cells in a non-image-forming visual circuit of mouse retina,” J. Neurosci., 35, No. 48, 15955–15970 (2015), https://doi.org/10.1523/JNEUROSCI.3382-15.2015.
Ortuno-Lizaran, I., Esquiva, G., Beach, T. G., et al., “Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s disease,” Acta Neuropathol. Comm., 6, No. 1, 1–10 (2018), https://doi.org/10.1186/s40478-018-0596-z.
Munteanu, T., Noronha, K. J., Leung, A. C., et al., “Light-dependent pathways for dopaminergic amacrine cells development and function,” eLife, 7, e39866 (2018), https://doi.org/10.7554/eLife.39866.
Miri, S., Glazman, S., and Bodis-Wollner, I., “OCT and Parkinson’s disease,” OCT in Central Nervous System Diseases (2016), pp. 105–121, https://doi.org/10.1007/978-3-319-24085-5_6.
Chrysou, A., Jansonius, N. M., and van Laar, T., “Retinal layers in Parkinson’s disease: A meta-analysis of spectral-domain optical coherence tomography studies,” Parkinsonism Relat. Disord., 64, 40–49 (2019), https://doi.org/10.1016/j.parkreldis.2019.04.023.
Pilat, A., McLean, R. J., Proudlock, F. A., et al., “In vivo morphology of optic nerve and retina in patients with Parkinson’s disease,” Invest. Ophthalmol. Vis. Sci., 57, No. 10, 4420–4427 (2016), https://doi.org/10.1167/iovs.16-20020.
Egorova, E. A., Glaucoma. National Guidelines, GEOTAR-Media, Moscow (2013).
Kaur, M., Saxena, R., Singh, D., et al., “Correlation between structural and functional retinal changes in Parkinson disease,” J. Neuroophthamol., 35, No. 3, 254–258 (2015), https://doi.org/10.1097/WNO.0000000000000240.
Ahn, J., Lee, J. Y., Kim, T. W., et al., “Retinal thinning associates with nigral dopaminergic loss in de novo Parkinson disease,” Neurology, 91, No. 11, e1003–e1012 (2018), https://doi.org/10.1212/WNL.0000000000006157.
Lee, J. J., Shin, N. Y., Lee, Y., et al., “Optic nerve integrity as a visuospatial cognitive predictor in Parkinson’s disease,” Parkinsonism Relat. Disord., 31, 41–45 (2016), https://doi.org/10.1016/j.parkreldis.2016.06.020.
Lee, J. Y., Ahn, J., Yoon, E. J., et al., “Macular ganglion-cell-complex layer thinning and optic nerve integrity in drug-naïve Parkinson’s disease,” J. Neural Transm. (Vienna), 126, No. 12, 1695–1699 (2019), https://doi.org/10.1007/s00702-019-02097-7.
Arrigo, A., Calamuneri, A., Milardi, D., et al., “Visual system involvement in patients with newly diagnosed Parkinson disease,” Radiology, 285, No. 3, 885–895 (2017), https://doi.org/10.1148/radiol.2017161732.
Ridder, A., Muller, M. L. T. M., Kotagal, V., et al., “Impaired contrast sensitivity is associated with more severe cognitive impairment in Parkinson disease,” Parkinsonism Relat. Disord., 34, 15–19 (2017), https://doi.org/10.1016/j.parkreldis.2016.10.006.
Anang, J. B. M., Gagnon, J. F., Bertrand, J. A., et al., “Predictors of dementia in Parkinson’s disease: A prospective cohort study,” Neurology, 83, No. 14, 1253–1260 (2014), https://doi.org/10.1212/WNL.0000000000000842.
Murueta-Goyena, A., Del Pino, R., Galdós, M., et al., “Retinal thickness predicts the risk of cognitive decline in Parkinson disease,” Ann. Neurol., 89, No. 1, 165–176 (2021), https://doi.org/10.1002/ana.25944.
Leyland, L.-A., Bremner, F. D., Mahmood, R., et al., “Visual tests predict dementia risk in Parkinson disease,” Neurol. Clin. Pract., 10, No. 1, 29–39 (2020), https://doi.org/10.1212/CPJ.0000000000000719.
Weil, R. S., Schrag, A. E., Warren, J. D., et al., “Visual dysfunction in Parkinson’s disease,” Brain, 139, No. 11, 2827–2843 (2016), https://doi.org/10.1093/brain/aww175.
Bohnen, N. I., Koeppe, R. A., Minoshima, S., et al., “Cerebral glucose metabolic features of Parkinson’s disease and incident dementia: longitudinal study,” J. Nucl. Med., 52, No. 6, 858–855 (2011), https://doi.org/10.2967/jnumed.111.089946.
Lenka, A., Jhunjhunwala, K. R., Saini, J., and Pal, P. K., “Structural and functional neuroimaging in patients with Parkinson’s disease and visual hallucinations: A critical review,” Parkinsonism Relat. Disord., 21, No. 7, 683–691 (2015), https://doi.org/10.1016/j.parkreldis.2015.04.005.
Barrell, K., Bureau, B., Turcano, P., et al., “High-order visual processing, visual symptoms, and visual hallucinations: A possible symptomatic progression of Parkinson’s disease,” Front. Neurol., 9, 999 (2018), https://doi.org/10.3389/fneur.2018.00999.
O’Callaghan, C., Hall, J. M., Tomassini, A., et al., “Visual hallucinations are characterized by impaired sensory evidence accumulation: insights from hierarchical drift diffusion modeling in Parkinson’s disease,” Biol. Psychiatry Cogn. Neurosci. Neuroimaging, 2, No. 8, 680–688 (2017), https://doi.org/10.1016/j.bpsc.2017.04.007.
Pagonabarraga, J., Martinez-Horta, S., de Bobadilla, R. F., et al., “Minor hallucinations occur in drug-naive Parkinson’s disease patients, even from the premotor phase,” Mov. Disord., 31, No. 1, 45–52 (2016), https://doi.org/10.1002/mds.26432.
Lenka, A., Pagonabarraga, J., Pal, P. K., et al., “Minor hallucinations in Parkinson’s disease: A subtle symptom with major clinical implications,” Neurology, 93, No. 6, 259–266 (2019), https://doi.org/10.1212/WNL.0000000000007913.
Lee, W.-W., Yoon, E. J., Lee, J.-Y., et al., “Visual hallucinations and pattern of brain degeneration in Parkinson’s disease,” Neurodegener. Dis., 17, No. 2–3, 62–72 (2017), https://doi.org/10.1159/000448517.
Aarsland, D., Batzu, L., Halliday, G. M., et al., “Parkinson disease-associated cognitive impairment,” Nat. Rev. Dis. Primers, 7, No. 1, 1–21 (2021), https://doi.org/10.1038/s41572-021-00280-3.
Hermanowicz, N. and Edwards, K., “Parkinson’s disease psychosis: symptoms, management, and economic burden,” Am. J. Manag. Care, 21, No. 10, Supplement, s199–s206 (2015).
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 122, No. 11, Iss. 2, pp. 5–11, November, 2022.
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Nikitina, A.Y., Melnikova, N.V., Moshetova, L.K. et al. Visual Impairments in Parkinson’s Disease. Neurosci Behav Physi 53, 952–958 (2023). https://doi.org/10.1007/s11055-023-01487-5
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DOI: https://doi.org/10.1007/s11055-023-01487-5