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Macular ganglion-cell-complex layer thinning and optic nerve integrity in drug-naïve Parkinson’s disease

  • Neurology and Preclinical Neurological Studies - Short communication
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Abstract

To reveal the macular inner retinal change linked to axonal degeneration in Parkinson’s disease (PD), we performed macular optical coherence tomography scan and diffusion tensor imaging of the retrobulbar optic nerve on both eyes of 36 drug-naïve PD patients. Thicknesses of inner retinal layers were automatically measured, and correlation analysis was conducted between the retinal thickness and diffusion parameters of the optic nerve. PD patients showed thinning of the inner retinal layers compared to control data. Thicknesses of the ganglion cell and inner plexiform layers were both correlated positively with fractional anisotropy and negatively with diffusivity indices of ipsilateral optic nerve (FDR-adjusted p < 0.05). This study revealed a novel in vivo connection between macular parafoveal ganglion cell change and integrity in the retrobulbar optic nerve in drug-naïve PD.

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Funding

This work was supported by a National Research Foundation (NRF) grant funded by the Ministry of Education, Science and Technology (MEST) in Korea (NRF-2018R1C1B3008971) and by a clinical research grant-in-aid from the Seoul Metropolitan Government Seoul National University (SMG-SNU) Boramae Medical Center (03-2015-8).

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Authors and Affiliations

  1. Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, College of Medicine, Seoul National University, Boramae 5 Road 20, Shindaebang-dong, Dongjak-gu, Seoul, Republic of Korea

    Jee-Young Lee

  2. Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, College of Medicine, Seoul National University, Seoul, South Korea

    Jeeyun Ahn

  3. Department of Nuclear Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea

    Eun Jin Yoon & Yu Kyeong Kim

  4. Department of Biomedical Statistics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea

    Sohee Oh

  5. Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, South Korea

    Beomseok Jeon

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  1. Jee-Young Lee
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  2. Jeeyun Ahn
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  3. Eun Jin Yoon
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  4. Sohee Oh
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  5. Yu Kyeong Kim
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  6. Beomseok Jeon
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Correspondence to Jee-Young Lee.

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Conflict of interest

J.-Y. Lee, J. Ahn, E. J. Yun, S. Oh, Y. K. Kim, and B. Jeon report there are no potential conflicts of interest related to this work.

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Lee, JY., Ahn, J., Yoon, E.J. et al. Macular ganglion-cell-complex layer thinning and optic nerve integrity in drug-naïve Parkinson’s disease. J Neural Transm 126, 1695–1699 (2019). https://doi.org/10.1007/s00702-019-02097-7

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  • DOI: https://doi.org/10.1007/s00702-019-02097-7

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