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The Dorsal and Ventral Hippocampus Have Different Reactivities to Proinflammatory Stress: Corticosterone Levels, Cytokine Expression, and Synaptic Plasticity

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The dorsal and ventral parts of the hippocampus are functionally and morphologically nonidentical, and differences include stress reactivity. The present report describes the first study of the influence of proinflammatory stress induced by administration of lipopolysaccharide on the functional state and levels of the stress hormone corticosterone and proinflammatory cytokines in the dorsal (DH) and ventral (VH) hippocampus as compared with the neocortex, as well as changes in blood levels. The DH and VH responded specifically to proinflammatory stress: neurological inflammation developed more quickly in the DH, while corticosterone accumulation occurred more quickly in the neocortex and VH; functionally (in terms of the state of synaptic plasticity and the phenomenon of in vivo long-term potentiation), the DH suffered first, impairments then spreading to the VH.

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    M. V. Onufriev, Sh. S. Uzakov, S. V. Freiman, M. Yu. Stepanichev, Yu. V. Moiseeva, N. A. Lazareva, V. A. Markevich & N. V. Gulyaeva

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  1. M. V. Onufriev
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  2. Sh. S. Uzakov
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  3. S. V. Freiman
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  4. M. Yu. Stepanichev
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  5. Yu. V. Moiseeva
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  6. N. A. Lazareva
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  7. V. A. Markevich
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  8. N. V. Gulyaeva
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Correspondence to M. V. Onufriev.

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 67, No. 3, pp. 349–358, May–June, 2017.

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Onufriev, M.V., Uzakov, S.S., Freiman, S.V. et al. The Dorsal and Ventral Hippocampus Have Different Reactivities to Proinflammatory Stress: Corticosterone Levels, Cytokine Expression, and Synaptic Plasticity. Neurosci Behav Physi 48, 1024–1031 (2018). https://doi.org/10.1007/s11055-018-0665-6

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  • DOI: https://doi.org/10.1007/s11055-018-0665-6

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