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Immunolocation of Heme Oxygenases in the Walls of Cerebral Arteries of Various Diameters in Rats

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Bulletin of Experimental Biology and Medicine Aims and scope

The distribution of two enzymes involved in the formation of carbon monoxide, heme oxygenases 1 and 2, in the pial branches of orders I-V of the middle cerebral artery basin and in intracerebral vessels was studied in adult Wistar rats. Immunohistochemical studies detected hemeoxygenase-2 in the endothelium of the small pial and intracerebral arterioles and in myocytes of pial branches I-III. Heme oxygenase 1, an inducible form of the enzyme, is normally not expressed in the cerebral vessels, but the enzyme is expressed in response to sodium metaarsenite. In this case, heme oxygenase markers are detected in myocytes of pial arteries I-II and in the endothelium of small pial and intracerebral vessels. Sodium meta-arsenite is inessential for immunolocation and quantitative distribution of heme oxygenase 2 in the vessels.

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Authors and Affiliations

  1. Department of Human Anatomy, Pacific State Medical University, the Ministry of Health of the Russian Federation, Vladivostok, Russia

    V. M. Chertok & A. E. Kotsyuba

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  1. V. M. Chertok
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  2. A. E. Kotsyuba
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Correspondence to V. M. Chertok.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 2, pp. 246-250, February, 2017

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Chertok, V.M., Kotsyuba, A.E. Immunolocation of Heme Oxygenases in the Walls of Cerebral Arteries of Various Diameters in Rats. Bull Exp Biol Med 163, 276–279 (2017). https://doi.org/10.1007/s10517-017-3783-1

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  • DOI: https://doi.org/10.1007/s10517-017-3783-1

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