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Local Protein Synthesis in Dendritic Terminals and Its Regulation in Normal Conditions and during Plastic Changes

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This review discusses the features and basic mechanisms of regulation of compartmentalized protein synthesis in dendrites. The current literature on this question is analyzed. Results of numerous experiments using molecular-biological, cytological, and physiological methods are presented. The review also contains information on various nervous system diseases for which a connection with impairments to protein translation in dendrites has been demonstrated.

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  1. Laboratory for the Cellular Neurobiology of Learning, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    E. A. Chesnokova & P. M. Kolosov

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  1. E. A. Chesnokova
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  2. P. M. Kolosov
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Correspondence to E. A. Chesnokova.

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 66, No. 2, pp. 163–180, March–April, 2016.

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Chesnokova, E.A., Kolosov, P.M. Local Protein Synthesis in Dendritic Terminals and Its Regulation in Normal Conditions and during Plastic Changes. Neurosci Behav Physi 47, 595–607 (2017). https://doi.org/10.1007/s11055-017-0440-0

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